School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala 147 004, India.
School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala 147 004, India.
Bioorg Chem. 2021 Mar;108:104633. doi: 10.1016/j.bioorg.2021.104633. Epub 2021 Jan 12.
8-Hydroxyquinoline (8-HQ) is a significant heterocyclic scaffold in organic and analytical chemistry because of the properties of chromophore and is used to detect various metal ions and anions. But from the last 2 decades, this moiety has been drawn great attention of medicinal chemists due to its significant biological activities. Synthetic modification of 8-hydroxyquinoline is under exploration on large scale to develop more potent target-based broad spectrum drug molecules for the treatment of several life-threatening diseases such as anti-cancer, HIV, neurodegenerative disorders, etc. Metal chelation properties of 8-hydroxyquinoline and its derivatives also make these potent drug candidates for the treatment of various diseases. This review comprises 8-hydroxyquinoline derivatives reported in the literature in last five years (2016-2020) and we anticipate that it will assist medicinal chemists in the synthesis of novel and pharmacologically potent agents for various therapeutic targets, mainly anti-proliferative, anti-microbial, anti-fungal and anti-viral as well as for the treatment of neurodegenerative disorders.
8-羟基喹啉（8-HQ）是有机和分析化学中重要的杂环支架，由于其发色团的性质，被用于检测各种金属离子和阴离子。但在过去的 20 年里，由于其显著的生物活性，这个部分引起了药物化学家的极大关注。为了开发出更有效的基于靶点的广谱药物分子，用于治疗多种危及生命的疾病，如癌症、艾滋病、神经退行性疾病等，对 8-羟基喹啉的合成修饰正在大规模进行探索。8-羟基喹啉及其衍生物的金属螯合特性也使这些潜在药物成为治疗各种疾病的候选药物。本文综述了过去五年（2016-2020 年）文献中报道的 8-羟基喹啉衍生物，我们期望它能帮助药物化学家合成新型、具有药理活性的药物，用于治疗各种治疗靶点，主要是抗增殖、抗微生物、抗真菌和抗病毒，以及治疗神经退行性疾病。
