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从柬埔寨马德望非腹泻儿童粪便样本中分离出的耐抗菌药物。

Antimicrobial resistant isolated from non-diarrheal child stool sample in Battambang, Cambodia.

作者信息

Ruksasiri Supaporn, Lurchachaiwong Woradee, Wassanarungroj Patcharawalai, Serichantalergs Oralak, Sivhour Chiek, Samon Nou, Ly Sovann, Chanthap Lon, Bodhidatta Ladaporn, Crawford John

机构信息

1Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok, 10400 Thailand.

Battambang Referral Hospital, PrekMohatep Village, SvayPor Commune, Battambang, Cambodia.

出版信息

Gut Pathog. 2018 May 30;10:18. doi: 10.1186/s13099-018-0246-9. eCollection 2018.

Abstract

() is associated with human gastroenteritis; however, was isolated and confirmed by phenotypic and genotypic identification from a non-diarrheal child stool sample in Cambodia. Antimicrobial susceptibility testing demonstrated that this isolate had a high minimal inhibitory concentration against macrolides and quinolones, which are first-line antibiotic treatment choices for infections. Consequently, macrolides and quinolones were likewise expected to be ineffective against -like organisms such as . This isolate warranted further genetic characterization to better understand associated antibiotic resistance mechanisms. Resistant pathogens from asymptomatic diarrheal cases are likely underestimated, and as such colonized individuals may spread resistant organisms to local community members and the environment.

摘要

()与人类肠胃炎相关;然而,在柬埔寨从一名无腹泻症状儿童的粪便样本中通过表型和基因型鉴定分离并确认了(此处原文缺失相关信息)。抗菌药敏试验表明,该分离株对大环内酯类和喹诺酮类药物具有较高的最低抑菌浓度,而大环内酯类和喹诺酮类药物是(此处原文缺失相关信息)感染的一线抗生素治疗选择。因此,大环内酯类和喹诺酮类药物同样预计对诸如(此处原文缺失相关信息)等类似(此处原文缺失相关信息)的生物体无效。该分离株需要进一步的基因特征分析,以更好地了解相关的抗生素耐药机制。无症状腹泻病例中的耐药病原体可能被低估,因此定植个体可能会将耐药生物体传播给当地社区成员和环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01b/5975586/62684c1e3bec/13099_2018_246_Fig1_HTML.jpg

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