Nutrition Department, Institute of Mother and Child, Warsaw, Poland.
Clinic of Pediatrics, Gastrology and Children's Rheumatology, Pomeranian Medical University, Szczecin, Poland.
Oxid Med Cell Longev. 2018 May 2;2018:1324820. doi: 10.1155/2018/1324820. eCollection 2018.
Oxidative stress is a factor involved in the pathogenesis of celiac disease (CD), possibly affecting the course of the disease and celiac-related complications. We assessed the intensity of oxidative processes and the efficiency of antioxidant defense in children with celiac disease. Group I ( = 32) consisted of children with CD treated with a gluten-free diet, and group II ( = 24) consisted of healthy children on a traditional diet. Antioxidative and oxidative status was assessed by measurement of serum total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidized low-density lipoprotein (ox-LDL) and on the basis of oxidative stress index (OSI).
There were no significant differences in serum TAC, TOC, ox-LDL, and OSI between children with CD and healthy children. Cluster analysis showed that the group of children with CD is not homogeneous in terms of serum TAC and TOC levels. About 50% of these children had TAC levels < 1.3 mmol/L and TOC levels > 0.35 mmol/L.
Strict adherence to a gluten-free diet by children with CD seems to be important for maintaining oxidative-antioxidant balance. However, further research is needed to identify factors potentially responsible for increased oxidative stress in some children with celiac disease despite adherence to a gluten-free diet.
氧化应激是乳糜泻（CD）发病机制的一个因素，可能影响疾病的进程和乳糜泻相关并发症。我们评估了乳糜泻患儿氧化过程的强度和抗氧化防御的效率。I 组（n=32）由接受无麸质饮食治疗的 CD 患儿组成，II 组（n=24）由传统饮食的健康儿童组成。通过测量血清总抗氧化能力（TAC）、总氧化能力（TOC）、氧化型低密度脂蛋白（ox-LDL）和基于氧化应激指数（OSI）来评估抗氧化和氧化状态。
CD 患儿和健康儿童的血清 TAC、TOC、ox-LDL 和 OSI 无显著差异。聚类分析显示，CD 患儿组在血清 TAC 和 TOC 水平上并不均匀。这些儿童中有大约 50%的 TAC 水平<1.3mmol/L 和 TOC 水平>0.35mmol/L。
严格遵循无麸质饮食对 CD 患儿维持氧化-抗氧化平衡很重要。然而，需要进一步研究以确定尽管遵循无麸质饮食，但某些乳糜泻患儿中氧化应激增加的潜在原因。
