病毒对 TLRs 和细胞因子的调节及其相关免疫疗法在 HPV 相关癌症中的应用。
Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers.
机构信息
Laboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Center of Biological Sciences, Federal University of Pernambuco, Av. Prof Moraes Rego, 1235 Cidade Universitária 50670-901 Recife, PE, Brazil.
Laboratory of Immunological and Antitumor Analysis (LAIA), Department of Antibiotics, Center of Biological Sciences, Federal University of Pernambuco, Av. Prof Artur de Sá, s/n, Cidade Universitária 50740-525 Recife, PE, Brazil.
出版信息
J Immunol Res. 2018 May 2;2018:2912671. doi: 10.1155/2018/2912671. eCollection 2018.
The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers. This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling. Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells. Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools.
宿主固有免疫系统的调节是多种肿瘤（包括人乳头瘤病毒（HPV）相关癌症）发生的一个成熟的致癌特征。这种病毒能够中断免疫反应的初始事件，包括 Toll 样受体（TLR）、细胞因子和炎症的表达。TLR 和细胞因子在 HPV 的识别、细胞成熟和分化以及免疫信号传导中都起着核心作用。因此，这种对免疫反应的敏感控制失衡是开发免疫疗法的关键因素，这些疗法可以增强宿主免疫系统，有效地抵御 HPV 和 HPV 感染的细胞。基于此，本综述旨在揭示涉及 TLR 和细胞因子的 HPV 免疫逃逸机制，并讨论现有的和潜在的免疫治疗 TLR 和细胞因子相关工具。
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