Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, 123 Muscat, Oman.
Centre de Recherche du CHUM (CRCHUM) et Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.
J Immunol Res. 2018 Apr 30;2018:9480497. doi: 10.1155/2018/9480497. eCollection 2018.
The role of the innate immune response in detecting RNA viruses is crucial for the establishment of proper inflammatory and antiviral responses. Different receptors, known as pattern recognition receptors (PRRs), are present in the cytoplasm, endosomes, and on the cellular surface. These receptors have the capacity to sense the presence of viral nucleic acids as pathogen-associated molecular patterns (PAMPs). This recognition leads to the induction of type 1 interferons (IFNs) as well as inflammatory cytokines and chemokines. In this review, we provide an overview of the significant involvement of cellular RNA helicases and Toll-like receptors (TLRs) 3, 7, and 8 in antiviral immune defenses.
先天免疫反应在检测 RNA 病毒方面起着至关重要的作用，对于建立适当的炎症和抗病毒反应至关重要。不同的受体，被称为模式识别受体 (PRRs)，存在于细胞质、内体和细胞表面。这些受体能够感知病毒核酸作为病原体相关分子模式 (PAMPs) 的存在。这种识别导致诱导 I 型干扰素 (IFNs) 以及炎症细胞因子和趋化因子。在这篇综述中，我们概述了细胞 RNA 解旋酶和 Toll 样受体 (TLRs) 3、7 和 8 在抗病毒免疫防御中的重要作用。
