Moore Chris B, Ting Jenny P-Y
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Immunity. 2008 Jun;28(6):735-9. doi: 10.1016/j.immuni.2008.05.005.
Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.
线粒体抗病毒免疫涉及属于RIG-I样解旋酶家族的细胞内模式识别受体（PRR）对病毒RNA的检测。这些信号分子和其他信号分子在外线粒体膜处汇聚，导致包括I型干扰素在内的抗病毒细胞因子迅速诱导产生。在此，我们讨论了描述参与调节这种抗病毒反应的新分子的近期研究。
