Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Neurogastroenterol Motil. 2018 Oct;30(10):e13379. doi: 10.1111/nmo.13379. Epub 2018 Jun 1.
Among patients with irritable bowel syndrome (IBS), atopic disease has been proposed as a common comorbidity increasing the IBS symptom burden. We therefore assessed the prevalence of self-reported atopy among patients with IBS as compared to non-IBS controls, and whether atopy and higher serum IgE levels were associated with increased IBS symptom severity.
Levels of total and specific IgE in serum were measured and questionnaires assessing the presence of atopic disease (ie, eczema, asthma, rhinoconjunctivitis, and pollen allergy), gastrointestinal symptom burden, food intolerance, somatic, and psychological symptoms were completed.
In total, 223 patients with IBS and 47 controls participated. Presence of atopic disease was reported in 55% of patients with IBS compared to 40% of controls (P = .07). IBS patients with atopic manifestations (N = 123) had higher total serum IgE levels (median 31 vs 16 kU /L, P < .001) and higher prevalence of self-reported food intolerance (28% vs 9%, P = .002) than non-atopic IBS patients (N = 100), respectively, but no major difference in gastrointestinal or psychological symptom burden was noted. However, severe somatic symptoms were more common among atopic than non-atopic patients with IBS (38% vs 27%, P = .028). We found no associations between self-reported atopy and IBS symptom severity using linear regression models.
CONCLUSIONS & INFERENCES: Atopic disease is common in patients with IBS, but that is also true for subjects without IBS. The presence of atopic disease in IBS is associated with self-reported food intolerance and somatic symptom severity, but unrelated to IBS symptom severity.
在肠易激综合征（IBS）患者中，特应性疾病被认为是一种常见的合并症，会增加 IBS 症状负担。因此，我们评估了 IBS 患者与非 IBS 对照者中自我报告的特应性的患病率，以及特应性和更高的血清 IgE 水平是否与 IBS 症状严重程度增加相关。
测量血清中的总 IgE 和特异性 IgE 水平，并完成评估特应性疾病（即湿疹、哮喘、鼻结膜炎和花粉过敏）、胃肠道症状负担、食物不耐受、躯体和心理症状存在的问卷。
共有 223 名 IBS 患者和 47 名对照者参与了研究。与对照组（40%）相比，IBS 患者中有 55%报告存在特应性疾病（P =.07）。有特应性表现的 IBS 患者（N=123）的总血清 IgE 水平更高（中位数 31 与 16 kU/L，P<0.001），自我报告的食物不耐受率更高（28%与 9%，P=0.002），而非特应性 IBS 患者（N=100）则不然，但胃肠道或心理症状负担无明显差异。然而，特应性 IBS 患者比非特应性 IBS 患者更常见严重的躯体症状（38%与 27%，P=0.028）。我们使用线性回归模型发现，自我报告的特应性与 IBS 症状严重程度之间无关联。
特应性疾病在 IBS 患者中很常见，但在无 IBS 的患者中也很常见。IBS 患者中特应性疾病的存在与自我报告的食物不耐受和躯体症状严重程度相关，但与 IBS 症状严重程度无关。
