Artini Paolo G, Obino Maria E, Vergine Francesca, Sergiampietri Claudia, Papini Francesca, Cela Vito
Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy -
Minerva Ginecol. 2018 Dec;70(6):738-749. doi: 10.23736/S0026-4784.18.04247-8. Epub 2018 May 31.
Over the past four decades, the postponement of childbearing has continued to increase, significantly impacting the age of first-time mothers. Female age is the most significant factor influencing clinical outcome in in-vitro fertilization. To overcome the limits of the age-related decline of fertility is a challenge for fertility experts. In the decrease of fertility in late reproductive age, a lot of factors related with advancing women's age and general health can be considered, however the dominant regulator of this age-dependent loss of fertility is the ovary. The key factors in the ovarian aging are oxidative stress, abnormalities of the meiotic spindle, decrease of function and number of oocyte mitochondria, alteration of sirtuins and androgen deficiency. The aim of this review was to assess the main biological factors involved in the female reproductive ageing according to the recent literature, focusing on oocyte-dependent ones, as well as the possible therapeutic strategies in assisted reproductive technique.
在过去的四十年里，生育推迟现象持续增加，这对初育母亲的年龄产生了重大影响。女性年龄是影响体外受精临床结局的最重要因素。克服与年龄相关的生育能力下降的限制是生育专家面临的一项挑战。在晚育年龄生育能力下降的过程中，可以考虑许多与女性年龄增长和总体健康相关的因素，然而，这种与年龄相关的生育能力丧失的主要调节因素是卵巢。卵巢衰老的关键因素包括氧化应激、减数分裂纺锤体异常、卵母细胞线粒体功能和数量下降、沉默调节蛋白改变以及雄激素缺乏。本综述的目的是根据最近的文献评估女性生殖衰老中涉及的主要生物学因素，重点关注依赖卵母细胞的因素，以及辅助生殖技术中可能的治疗策略。
