卵巢衰老及其对女性生育能力的影响。
Ovarian ageing and the impact on female fertility.
作者信息
Vollenhoven Beverley, Hunt Sarah
机构信息
Monash Health, Clayton, VIC, Australia.
Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
出版信息
F1000Res. 2018 Nov 22;7. doi: 10.12688/f1000research.16509.1. eCollection 2018.
Abstract
Female fertility decreases with increasing age, a reflection of declining oocyte quantity and quality. The menopausal transition occurs when the oocyte quantity falls below a threshold level. The pattern of follicular depletion as well as the factors, timing and mechanisms surrounding both declining oocyte number and oocyte quality remain incompletely understood. Further studies are needed to examine the factors involved and develop predictive models and biomarkers to assist in the management of age-related subfertility. This review summarises the current knowledge addressing the ageing ovary and its impact on fertility.
摘要
女性生育能力随年龄增长而下降，这反映了卵母细胞数量和质量的下降。当卵母细胞数量降至阈值水平以下时，就会出现更年期过渡。卵泡耗竭的模式以及围绕卵母细胞数量和质量下降的因素、时间和机制仍未完全了解。需要进一步研究以检查其中涉及的因素，并开发预测模型和生物标志物，以协助管理与年龄相关的生育力低下问题。本综述总结了目前关于衰老卵巢及其对生育能力影响的知识。
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