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通过表达白血病抑制因子（LIF）和整合素增强子宫内膜容受性

Enhancement of Endometrial Receptivity by through Expressing LIF and Integrins.

作者信息

Chung Tae-Wook, Park Mi-Ju, Lee Hoyoung, Kim Keuk-Jun, Kim Cheorl-Ho, Choi Hee-Jung, Ha Ki-Tae

机构信息

Department of Korean Medical Science, School of Korean Medicine and Healthy Aging Korean Medical Research Center, Pusan National University, Yangsan, Gyeongnam, Republic of Korea.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2019 Nov 16;2019:7560631. doi: 10.1155/2019/7560631. eCollection 2019.

DOI:10.1155/2019/7560631
PMID:31827559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6885254/
Abstract

Improvement of endometrial receptivity is necessary for successful embryo implantation, and its impairment is associated with female infertility. In this study, we investigated the effect of the roots of Makino (CoM) on endometrial receptivity in both in vitro and in vivo model of embryo implantation. We found that CoM enhanced the adhesion of JAr cells to Ishikawa cells by stimulating expression of leukemia inhibitory factor (LIF) and integrins. In addition, blocking of LIFR using hLA or neutralization of integrins V, 3, and 5 using antibodies significantly reduced the enhanced adhesion between JAr cell and CoM-treated Ishikawa cells, indicating that LIF and integrin play an important role in trophoblast-endometrium adhesion for embryo implantation. Furthermore, we identified that CoM significantly improved the implantation rate of blastocysts in the mouse model of RU-induced implantation failure. By collecting these results, here, we suggest that CoM has a therapeutic potential against female infertility associated with decreased endometrial receptivity.

摘要

改善子宫内膜容受性是胚胎成功着床所必需的，而其受损与女性不孕有关。在本研究中，我们在胚胎着床的体外和体内模型中研究了牧野党参（CoM）根对子宫内膜容受性的影响。我们发现，CoM通过刺激白血病抑制因子（LIF）和整合素的表达，增强了JAr细胞与石川细胞的黏附。此外，使用hLA阻断LIFR或使用抗体中和整合素V、β3和β5可显著降低JAr细胞与CoM处理的石川细胞之间增强的黏附，表明LIF和整合素在胚胎着床的滋养层-子宫内膜黏附中起重要作用。此外，我们发现CoM显著提高了RU诱导的着床失败小鼠模型中囊胚的着床率。综合这些结果，我们在此表明，CoM对与子宫内膜容受性降低相关的女性不孕具有治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/ae6b00d7ced6/ECAM2019-7560631.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/453bfebafc2f/ECAM2019-7560631.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/266c01c39def/ECAM2019-7560631.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/3e0dacf17370/ECAM2019-7560631.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/5f4ffdf0cb46/ECAM2019-7560631.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/cdd70f0d2075/ECAM2019-7560631.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/ae6b00d7ced6/ECAM2019-7560631.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/453bfebafc2f/ECAM2019-7560631.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/266c01c39def/ECAM2019-7560631.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/3e0dacf17370/ECAM2019-7560631.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/5f4ffdf0cb46/ECAM2019-7560631.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/cdd70f0d2075/ECAM2019-7560631.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa5/6885254/ae6b00d7ced6/ECAM2019-7560631.006.jpg

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Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis.传统和现代的子宫内膜容受性标志物：系统评价和荟萃分析。
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