Renato Romero José, Krause Neto Walter, Sabbag da Silva Alexandre, Luiz Dos Santos Everton, Aurélio Added Marco, Pianca Eduardo, Florencio Gama Eliane, Rodrigues de Souza Romeu
Department of Physiotherapy, Guarulhos University, Guarulhos, Brazil.
Department of Physical Education, Laboratory of Morphoquantitative Studies and Immunohistochemistry, São Judas Tadeu University, São Paulo, Brazil.
Aging Male. 2020 Dec;23(4):251-256. doi: 10.1080/13685538.2018.1477932. Epub 2018 Jun 1.
Several studies have demonstrated that alcohol consumption can decrease bone density and alter its structure. However, most of the studies did not investigate the effects of specific alcoholic beverages. This study determined the effects of chronic consumption of cachaça (a Brazilian beverage containing alcohol) on body weight (BW), tibia bone density and on the tibia collagen density in middle-aged rats. Rats with 9 months old were submitted for 100 days, to a liquid diet of cachaça diluted in water with a progressive and controlled concentration (10°GL, 15°GL, 20°GL, 25°GL, and 30°GL). Chronic cachaça intake produced a significant decrease in BW and altered bone remodeling, decreasing trabecular bone density. In chronic cachaça-treated group (CT), the production of collagen fibers in bone tissue has predominantly green birefringence. It appears that they are immature fibers that do not exist in the control group, in which there are standard predominantly yellowish mature fibers. In conclusion, chronic cachaça consumption affects the structure of the tibial bone of middle-aged rats by decreasing the bone density and reducing the density of mature collagen fibers.
多项研究表明，饮酒会降低骨密度并改变其结构。然而，大多数研究并未调查特定酒精饮料的影响。本研究确定了长期饮用卡莎萨酒（一种含酒精的巴西饮料）对中年大鼠体重（BW）、胫骨骨密度和胫骨胶原蛋白密度的影响。将9个月大的大鼠给予浓度逐步控制的卡莎萨酒稀释液（10°GL、15°GL、20°GL、25°GL和30°GL）作为液体饮食，持续100天。长期摄入卡莎萨酒导致体重显著下降，并改变骨重塑，降低小梁骨密度。在长期接受卡莎萨酒治疗的组（CT组）中，骨组织中胶原纤维的产生主要呈现绿色双折射。似乎它们是不成熟的纤维，在对照组中不存在，对照组中主要是标准的淡黄色成熟纤维。总之，长期饮用卡莎萨酒通过降低骨密度和减少成熟胶原纤维密度，影响中年大鼠胫骨的结构。
