Tsanzi Embedzayi, Light Heather R, Tou Janet C
Human Nutrition and Foods, West Virginia University, Morgantown, WV 26506, USA.
Bone. 2008 May;42(5):960-8. doi: 10.1016/j.bone.2008.01.020. Epub 2008 Feb 15.
Consumption of sugar beverages has increased among adolescents. Additionally, the replacement of sucrose with high fructose corn syrup (HFCS) as the predominant sweetener has resulted in higher fructose intake. Few studies have investigated the effect of drinking different sugar-sweetened beverages on bone, despite suggestions that sugar consumption negatively impacts mineral balance. The objective of this study was to determine the effect of drinking different sugar-sweetened beverages on bone mass and strength. Adolescent (age 35d) female Sprague-Dawley rats were randomly assigned (n=8-9/group) to consume deionized distilled water (ddH2O, control) or ddH2O containing 13% w/v glucose, sucrose, fructose or high fructose corn syrup (HFCS-55) for 8weeks. Tibia and femur measurements included bone morphometry, bone turnover markers, determination of bone mineral density (BMD) and bone mineral content (BMC) by dual energy X-ray absorptiometry (DXA) and bone strength by three-point bending test. The effect of sugar-sweetened beverage consumption on mineral balance, urinary and fecal calcium (Ca) and phosphorus (P) was measured by inductively coupled plasma optical emission spectrometry. The results showed no difference in the bone mass or strength of rats drinking the glucose-sweetened beverage despite their having the lowest food intake, but the highest beverage and caloric consumption. Only in comparisons among the rats provided sugar-sweetened beverage were femur and tibia BMD lower in rats drinking the glucose-sweetened beverage. Differences in bone and mineral measurements appeared most pronounced between rats drinking glucose versus fructose-sweetened beverages. Rats provided the glucose-sweetened beverage had reduced femur and tibia total P, reduced P and Ca intake and increased urinary Ca excretion compared to the rats provided the fructose-sweetened beverage. The results suggested that glucose rather than fructose exerted more deleterious effects on mineral balance and bone.
青少年中含糖饮料的消费量有所增加。此外，用高果糖玉米糖浆（HFCS）替代蔗糖作为主要甜味剂导致果糖摄入量增加。尽管有研究表明糖的摄入会对矿物质平衡产生负面影响，但很少有研究调查饮用不同含糖饮料对骨骼的影响。本研究的目的是确定饮用不同含糖饮料对骨量和骨强度的影响。将35日龄的青春期雌性Sprague-Dawley大鼠随机分组（每组n = 8 - 9只），分别饮用去离子蒸馏水（ddH2O，对照组）或含有13% w/v葡萄糖、蔗糖、果糖或高果糖玉米糖浆（HFCS - 55）的ddH2O，持续8周。对胫骨和股骨的测量包括骨形态计量学、骨转换标志物、通过双能X线吸收法（DXA）测定骨矿物质密度（BMD）和骨矿物质含量（BMC）以及通过三点弯曲试验测定骨强度。通过电感耦合等离子体发射光谱法测量饮用含糖饮料对矿物质平衡、尿钙和粪钙以及磷的影响。结果显示，饮用葡萄糖甜味饮料的大鼠尽管食物摄入量最低，但饮料和热量消耗最高，其骨量和骨强度与其他组无差异。仅在饮用含糖饮料的大鼠之间比较时，饮用葡萄糖甜味饮料的大鼠股骨和胫骨的BMD较低。饮用葡萄糖和果糖甜味饮料的大鼠之间，骨骼和矿物质测量的差异最为明显。与饮用果糖甜味饮料的大鼠相比，饮用葡萄糖甜味饮料的大鼠股骨和胫骨的总磷减少、磷和钙摄入量减少且尿钙排泄增加。结果表明，葡萄糖而非果糖对矿物质平衡和骨骼产生了更有害的影响。
