儿童期癌症幸存者自我报告吸烟情况的错误分类。
Misclassification of self-reported smoking in adult survivors of childhood cancer.
机构信息
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.
出版信息
Pediatr Blood Cancer. 2018 Sep;65(9):e27240. doi: 10.1002/pbc.27240. Epub 2018 Jun 1.
We investigated misclassification rates, sensitivity, and specificity of self-reported cigarette smoking through serum cotinine concentration (liquid chromatography tandem mass spectrometry) among 287 adult survivors of childhood cancer. Overall, 2.5-6.7% and 19.7-36.9% of the self-reported never and past smokers had cotinine levels indicative of active smoking. Sensitivity and specificity of self-reported smoking were 57.5-67.1% and 96.6-99.2%. Misclassification was associated with younger age (OR = 3.2; 95% CI = 1.4-7.4), male (OR = 2.1; 95% CI = 1.1-4.0), and past (OR = 2.7; 95% CI = 1.3-5.8) or current (OR = 2.6; 95% CI = 1.0-6.6) marijuana use. After adjusting for tobacco-related variables, current marijuana use remained a significant risk for misclassification. Clinicians/researchers should consider bio-verification to measure smoking status among survivors.
我们通过血清可替宁浓度（液相色谱-串联质谱法）调查了 287 名成年儿童癌症幸存者中自我报告的吸烟情况的错误分类率、敏感性和特异性。总的来说，2.5-6.7%和 19.7-36.9%的自我报告从不吸烟和过去吸烟的人可替宁水平表明他们仍在吸烟。自我报告吸烟的敏感性和特异性分别为 57.5-67.1%和 96.6-99.2%。错误分类与年龄较小（OR=3.2；95%CI=1.4-7.4）、男性（OR=2.1；95%CI=1.1-4.0）、过去（OR=2.7；95%CI=1.3-5.8）或现在（OR=2.6；95%CI=1.0-6.6）使用大麻有关。在调整与烟草相关的变量后，当前大麻的使用仍然是错误分类的一个显著风险因素。临床医生/研究人员应该考虑生物验证来衡量幸存者的吸烟状况。
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