Torchilin V P
Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Biochem Soc Trans. 2007 Aug;35(Pt 4):816-20. doi: 10.1042/BST0350816.
CPPs (cell-penetrating peptides), including Tatp (transactivator of transcription peptide), have been successfully used for intracellular delivery of a wide variety of cargoes including various nanoparticulate pharmaceutical carriers such as liposomes, micelles and nanoparticles. Here, we will consider the major results obtained in this area with emphasis on Tatp-mediated delivery of liposomes and various transfection vectors. We will also address the development of 'smart' stimuli-sensitive nanocarriers, where the cell-penetrating function can only be activated when the nanocarrier is inside the biological target, thus minimizing the interaction with non-target cells.
细胞穿透肽（CPPs），包括转录激活因子肽（Tatp），已成功用于多种物质的细胞内递送，这些物质包括各种纳米颗粒药物载体，如脂质体、胶束和纳米粒子。在此，我们将探讨该领域取得的主要成果，重点是Tatp介导的脂质体和各种转染载体的递送。我们还将讨论“智能”刺激敏感纳米载体的发展，其中细胞穿透功能只有在纳米载体进入生物靶点内部时才能被激活，从而将与非靶细胞的相互作用降至最低。
