可见光照耀下药物相关杂环的脱羧烷基化反应。
Visible Light-Mediated Decarboxylative Alkylation of Pharmaceutically Relevant Heterocycles.
机构信息
Willard Henry Dow Laboratory, Department of Chemistry , University of Michigan , 930 North University Avenue , Ann Arbor , Michigan 48109 , United States.
出版信息
Org Lett. 2018 Jun 15;20(12):3487-3490. doi: 10.1021/acs.orglett.8b01250. Epub 2018 Jun 1.
Abstract
A net redox-neutral method for the decarboxylative alkylation of heteroarenes using photoredox catalysis is reported. Additionally, this method features the use of simple, commercially available carboxylic acid derivatives as alkylating agents, enabling the facile alkylation of a variety of biologically relevant heterocyclic scaffolds under mild conditions.
摘要
本文报道了一种通过光氧化还原催化实现杂芳烃脱羧烷基化的净还原-中性方法。此外，该方法还具有使用简单、商业可得的羧酸衍生物作为烷基化试剂的特点，能够在温和条件下实现多种具有生物相关性的杂环骨架的易得烷基化。
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