Teofili Luciana, Silini Antonietta R, Bianchi Maria, Valentini Caterina Giovanna, Parolini Ornella
a Policlinico Universitario A. Gemelli IRCCS , Banca del Sangue di Cordone Ombelicale UNICATT, Università Cattolica del Sacro Cuore , Rome , Italy.
b Centro di Ricerca "E. Menni" Fondazione Poliambulanza - Istituto Ospedaliero , Brescia , Italy.
Expert Rev Hematol. 2018 Aug;11(8):649-661. doi: 10.1080/17474086.2018.1483717. Epub 2018 Jul 14.
Human term placenta is comprised of various tissues from which different cells can be obtained, including hematopoietic stem cells and mesenchymal stem/stromal cells (MSCs). Areas covered: This review will discuss the possibility to incorporate placental tissue cells in cord blood banking. It will discuss general features of human placenta, with a brief review of the immune cells at the fetal-maternal interface and the different cell populations isolated from placenta, with a particular focus on MSCs. It will address the question as to why placenta-derived MSCs should be banked with their hematopoietic counterparts. It will discuss clinical trials which are studying safety and efficacy of placenta tissue-derived MSCs in selected diseases, and preclinical studies which have proven their therapeutic properties in other diseases. It will discuss banking of umbilical cord blood and raise several issues for improvement, and the applications of cord blood cells in non-malignant disorders. Expert commentary: Umbilical cord blood banking saves lives worldwide. The concomitant banking of non-hematopoietic cells from placenta, which could be applied therapeutically in the future, alone or in combination to their hematopoietic counterparts, could exploit current banking processes while laying the foundation for clinical trials exploring placenta-derived cell therapies in regenerative medicine.
足月人类胎盘由多种组织构成，可从中获取不同类型的细胞，包括造血干细胞和间充质干/基质细胞（MSCs）。涵盖领域：本综述将探讨在脐血库中纳入胎盘组织细胞的可能性。将讨论人类胎盘的一般特征，简要回顾胎儿-母体界面的免疫细胞以及从胎盘中分离出的不同细胞群体，特别关注间充质干细胞。将探讨为何胎盘来源的间充质干细胞应与其造血对应物一同储存。将讨论正在研究胎盘组织来源的间充质干细胞在特定疾病中的安全性和有效性的临床试验，以及已在其他疾病中证明其治疗特性的临床前研究。将讨论脐血库的相关问题并提出若干改进要点，以及脐血细胞在非恶性疾病中的应用。专家评论：脐血库在全球范围内挽救了许多生命。同时储存胎盘来源的非造血细胞，这些细胞未来可单独或与其造血对应物联合用于治疗，这既能利用现有的储存流程，又能为探索胎盘来源细胞疗法在再生医学中的临床试验奠定基础。
