CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
School of Transportation and Logistics, Southwest Jiaotong University, Chengdu, China.
PLoS One. 2018 Jun 1;13(6):e0198206. doi: 10.1371/journal.pone.0198206. eCollection 2018.
Mental fatigue is one of the main reasons for the decline of response inhibition. This study aimed to explore the impairing influence of mental fatigue on a driver's response inhibition. The effects of mental fatigue on response inhibition were assessed by comparing brain activity and behavioral indices when performing a Go/NoGo task before and after a 90-min fatigue manipulation task. Participants in the driving group performed a simulated driving task, while individuals in the control group spent the same time watching movies. We found that participants in the driving group reported higher levels of mental fatigue and had a higher percentage of eye closure and larger lateral deviations from their lane positions, which indicated there was effective manipulation of mental fatigue through a prolonged simulated driving task. After manipulation of mental fatigue, we observed increased reaction time and miss rates, delayed NoGo-N2 latency and Go-P3 latency, and decreased NoGo-P3 amplitude, which indicated that mental fatigue may slow down the speed of the inhibition process, delay the evaluation of visual stimuli and reduce the availability of attentional resources. These findings revealed the underlying neurological mechanisms of how mental fatigue impaired response inhibition.
精神疲劳是反应抑制下降的主要原因之一。本研究旨在探讨精神疲劳对驾驶员反应抑制的损害影响。通过比较执行 Go/NoGo 任务前后的大脑活动和行为指标，评估精神疲劳对反应抑制的影响。驾驶组的参与者执行模拟驾驶任务，而对照组的个体则花相同的时间观看电影。我们发现驾驶组的参与者报告了更高水平的精神疲劳，并且有更高比例的闭眼和更大的侧向偏离其车道位置，这表明通过长时间的模拟驾驶任务有效地进行了精神疲劳的操作。在精神疲劳操作后，我们观察到反应时间和错误率增加、NoGo-N2 潜伏期和 Go-P3 潜伏期延迟以及 NoGo-P3 振幅降低，这表明精神疲劳可能会减缓抑制过程的速度，延迟视觉刺激的评估并减少注意力资源的可用性。这些发现揭示了精神疲劳损害反应抑制的潜在神经机制。
