Gordin A, Mustajoki P, Pelkonen R
J Endocrinol Invest. 1985 Feb;8(1):73-5. doi: 10.1007/BF03350647.
The effect of ketanserin, a selective serotonin-2 (5-HT2) receptor blocking agent, on the secretion of anterior pituitary hormones was studied in 4 healthy volunteers. Ketanserin (10 mg) was administered as a slow iv injection and its effect was compared with that of saline. Ketanserin influenced neither the basal plasma levels of HGH, ACTH, TSH, LH or prolactin, nor the plasma levels of T4, T3, cortisol or glucose. Even if a single dose of ketanserin had no hormonal effects, this must also be studied after long term use.
在4名健康志愿者中研究了选择性5-羟色胺-2（5-HT2）受体阻断剂酮色林对垂体前叶激素分泌的影响。酮色林（10毫克）以缓慢静脉注射给药，并将其效果与生理盐水的效果进行比较。酮色林既不影响生长激素、促肾上腺皮质激素、促甲状腺激素、促黄体生成素或催乳素的基础血浆水平，也不影响甲状腺素、三碘甲状腺原氨酸、皮质醇或葡萄糖的血浆水平。即使单剂量的酮色林没有激素作用，长期使用后也必须对此进行研究。
