微管蛋白翻译后修饰及其与人类疾病的关联。
Tubulin Posttranslational Modifications and Emerging Links to Human Disease.
机构信息
Institut Curie, PSL Research University, CNRS UMR3348, Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR3348, Orsay, France.
Institut Curie, PSL Research University, CNRS UMR3348, Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR3348, Orsay, France.
出版信息
Cell. 2018 May 31;173(6):1323-1327. doi: 10.1016/j.cell.2018.05.018.
Tubulin posttranslational modifications are currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated in a number of disorders. Here, we review the latest advances in understanding the physiological roles of tubulin modifications and their links to a variety of pathologies.
微管蛋白翻译后修饰目前作为微管细胞骨架的重要调节剂而出现，因此很有可能与许多疾病有关。在这里，我们回顾了理解微管蛋白修饰的生理作用及其与各种病理的联系的最新进展。
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