Mizutani Tatsushi, Yoshimoto Takashi, Ishii Akira
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
Leg Med (Tokyo). 2018 May 21;33:53-54. doi: 10.1016/j.legalmed.2018.05.004.
We examined postmortem β-hydroxybutyrate (BHB) levels in the body fluids obtained from 253 forensic autopsy cases whose causes of death were determined. Postmortem changes of BHB levels according to postmortem intervals (PMI) in various body fluids (plasma, urine, vitreous humor, and pericardial fluids) were investigated to determine appropriate alternative specimens as plasma samples. Our study has indicated the following points: 1) the BHB levels in plasma specimens from three sampling sites showed no significant differences, 2) postmortem changes of BHB levels in plasma and pericardial fluids could be negligible within 96 h PMI, while urine and vitreous humor BHB levels showed postmortem changes, and 3) pericardial fluid would thus be most suitable as an alternative to plasma in postmortem BHB level. We have also proposed that BHB levels could be applicable for the diagnosis of metabolic disorders in forensic autopsy.
我们检测了253例死因已明确的法医尸检病例所获体液中的死后β-羟基丁酸（BHB）水平。研究了不同体液（血浆、尿液、玻璃体液和心包液）中BHB水平随死后间隔时间（PMI）的死后变化情况，以确定合适的替代血浆样本的标本。我们的研究表明了以下几点：1）来自三个采样部位的血浆标本中BHB水平无显著差异；2）在PMI 96小时内，血浆和心包液中BHB水平的死后变化可忽略不计，而尿液和玻璃体液中BHB水平出现死后变化；3）因此，心包液最适合作为死后BHB水平检测中血浆的替代物。我们还提出，BHB水平可应用于法医尸检中代谢紊乱的诊断。
