Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ 07103, USA.
Department of Medicine - Division of Hematology/Oncology, Rutgers, New Jersey Medical School, Newark, NJ 07103, USA.
Biochimie. 2018 Dec;155:92-103. doi: 10.1016/j.biochi.2018.05.018. Epub 2018 May 31.
The secretome produced by cells within the bone marrow is significant to homeostasis. The bone marrow, a well-studied organ, has multiple niches with distinct roles for supporting stem cell functions. Thus, an understanding of mediators involved in the regulation of stem cells could serve as a model for clinical problems and solutions such as tissue repair and regeneration. The exosome secretome of bone marrow stem cells is a developing area of research with respect to the regenerative potential by bone marrow cell, particularly the mesenchymal stem cells. The bone marrow niche regulates endogenous processes such as hematopoiesis but could also support the survival of tumors such as facilitating the cancer stem cells to exist in dormancy for decades. The bone marrow-derived secretome will be critical to future development of therapeutic strategies for oncologic diseases, in addition to regenerative medicine. This article discusses the importance for parallel studies to determine how the same secretome may compromise safety during the use of stem cells in regenerative medicine.
骨髓细胞产生的分泌组对于维持内环境稳定具有重要意义。骨髓是一个研究较为深入的器官，其中有多个龛位，各自对干细胞功能的支持起着不同的作用。因此，了解参与干细胞调控的介质可以为临床问题及解决方案（如组织修复和再生）提供模型。骨髓干细胞的外泌体分泌组是骨髓细胞再生潜能研究的一个新兴领域，特别是间充质干细胞。骨髓龛位调节着内源性过程，如造血，但也可以支持肿瘤的存活，例如促进癌症干细胞数十年的休眠状态。骨髓衍生的分泌组对于肿瘤疾病治疗策略的未来发展至关重要，除了再生医学。本文讨论了并行研究的重要性，以确定在再生医学中使用干细胞时，相同的分泌组如何在安全性方面造成影响。
