Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan; Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Clin Chim Acta. 2018 Sep;484:192-196. doi: 10.1016/j.cca.2018.05.060. Epub 2018 Jun 1.
To elucidate the impact of fertility treatment on neonatal respiratory outcomes and amniotic lamellar body counts (LBCs) in twin pregnancies.
One hundred ninety twin pairs, including 99 dichorionic twin (DCT) and 91 monochorionic twin (MCT) pairs were registered at our institutions. All amniotic fluid samples were obtained from each sac at cesarean section. Samples were analyzed immediately after arrival at the laboratory without centrifugation. We divided the patients into 3 groups: the no therapy group (natural conception), the induced ovulation group (with or without intrauterine insemination), and the assisted reproductive technology (ART) group (in vitro fertilization or intracytoplasmic sperm injection).
No statistically significant associations between the fertility treatment and the rates of neonatal RDS/TTN were observed in the whole study population (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.45-2.00), DCT (OR, 0.86; 95%CI, 0.30-2.47), and MCT (OR, 1.45; 95%CI, 0.41-5.11). In addition, there was no association between the fertility treatment and neonatal RDS/TTN in the propensity score analysis of the whole study population (OR, 1.25; 95%CI, 0.57-2.74).
None of the individual types of fertility treatment had a direct impact on respiratory disorders such as RDS and TTN in twin infants.
阐明生育治疗对双胎妊娠新生儿呼吸结局和羊膜板层小体计数（LBC）的影响。
在我们的机构中登记了 190 对双胞胎，包括 99 对双绒毛膜双胞胎（DCT）和 91 对单绒毛膜双胞胎（MCT）。所有羊水样本均在剖宫产时从每个囊获得。样本在到达实验室后立即进行分析，无需离心。我们将患者分为 3 组：无治疗组（自然受孕）、诱导排卵组（有或没有宫腔内人工授精）和辅助生殖技术（ART）组（体外受精或胞浆内精子注射）。
在整个研究人群中，生育治疗与新生儿 RDS/TTN 的发生率之间没有统计学显著关联（优势比[OR]，0.95；95%置信区间[CI]，0.45-2.00）、DCT（OR，0.86；95%CI，0.30-2.47）和 MCT（OR，1.45；95%CI，0.41-5.11）。此外，在整个研究人群的倾向评分分析中，生育治疗与新生儿 RDS/TTN 之间也没有关联（OR，1.25；95%CI，0.57-2.74）。
单独的生育治疗类型都不会对双胞胎婴儿的呼吸障碍（如 RDS 和 TTN）产生直接影响。
