BCNatal-Fetal Medicine Research Center (Hospital Clínic-Maternitat and Hospital Sant Joan de Déu), University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Carrer Sabino de Arana 1, 08028, Barcelona, Spain.
Obstetrics Department, Hospital Santo Tomás, Universidad de Panamá (On behalf of the Iberoamerican Research Network in Obstetrics, Gynecology and Traslational Medicine), Panama City, Panama.
Sci Rep. 2022 May 30;12(1):9016. doi: 10.1038/s41598-022-13047-x.
To evaluate the concordance of the risk of neonatal respiratory morbidity (NRM) assessed by quantitative ultrasound lung texture analysis (QuantusFLM) between twin fetuses of the same pregnancy. Prospective study conducted in twin pregnancies. Fetal ultrasound lung images were obtained at 26.0-38.6 weeks of gestation. Categorical (high or low) and continuous results of the risk of NRM were compared between twins. Fetal ultrasound lung images from 131 pairs (262 images) of twins were included. The images were classified into three gestational age ranges: Group 1 (26.0-29.6 weeks, 78 images, 39 pairs [29.8%]); Group 2 (30.0-33.6 weeks, 98 images, 49 pairs [37.4%]) and Group 3 (34.0-38.6 weeks, 86 images, 43 pairs [32.8%]). Concordance was good in Groups 1 and 3 and moderate in Group 2. In Groups 2 and 3 at least one fetus presented high-risk results in 26.5% and 11.6% of twin pairs, respectively. Only gestational age < 32 weeks, gestational diabetes mellitus, and spontaneous conception were associated with a high risk of NRM in Group 2. There was good concordance of the risk of NRM between twins < 30.0 weeks and > 34.0 weeks. From 30.0 to 33.6 weeks 26.5% of the twin pairs had discordant results, with moderate concordance of the risk of NRM.
为了评估同一胎中双胞胎胎儿的定量超声肺纹理分析（QuantusFLM）评估的新生儿呼吸发病率（NRM）风险之间的一致性。在双胞胎妊娠中进行了前瞻性研究。在 26.0-38.6 孕周时获得胎儿超声肺图像。比较了双胞胎之间 NRM 风险的分类（高或低）和连续结果。纳入了 131 对（262 张）双胞胎的胎儿超声肺图像。这些图像分为三个胎龄范围：第 1 组（26.0-29.6 周，78 张图像，39 对[29.8%]）；第 2 组（30.0-33.6 周，98 张图像，49 对[37.4%]）和第 3 组（34.0-38.6 周，86 张图像，43 对[32.8%]）。第 1 组和第 3 组的一致性良好，第 2 组的一致性中等。在第 2 组和第 3 组中，分别有 26.5%和 11.6%的双胞胎中至少有一个胎儿呈现高危结果。仅<32 周的胎龄、妊娠期糖尿病和自然受孕与第 2 组的 NRM 高风险相关。在<30.0 周和>34.0 周的双胞胎中，NRM 风险具有良好的一致性。在 30.0 至 33.6 周之间，26.5%的双胞胎存在不一致的结果，NRM 风险的一致性中等。
