Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern 60 3000 Switzerland; Orygen, The National Centre of Excellence in Youth Mental Health & Centre for Youth Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.
Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern 60 3000 Switzerland.
Psychiatry Res Neuroimaging. 2018 Sep 30;279:40-50. doi: 10.1016/j.pscychresns.2018.05.011. Epub 2018 May 23.
This study examined the hypothesis that a fronto-temporal disconnection in the language network underpins formal thought disorder (FTD) in schizophrenia. Forty-nine patients with a schizophrenia spectrum disorder (27 with mild FTD, 22 with severe FTD) and 26 healthy controls (HC) were included. Overall psychopathology and FTD were assessed by the Positive and Negative Syndrome Scale and the Thought, Language, and Communication scale, respectively. White matter (WM) microstructure was analysed using Tract-Based Spatial Statistics. In patients, severity of overall FTD (TLC Sum Score) was predicted by decreased fractional anisotropy (FA) in the right superior longitudinal fasciculus (SLF), and severity of negative FTD (TLC Emptiness subscale) was predicted by increased FA in the left SLF and arcuate fasciculus (AF). Notably, these results were no longer significant after correction for multiple comparisons. Compared with HC, patients showed lower FA in all the investigated language-related WM tracts as well as across the whole WM skeleton. No difference in FA was found between patients with severe and patients with mild FTD. Our results are compatible with earlier studies reporting impairments in widely spread WM tracts including those related to language processing in patients with schizophrenia.
本研究检验了这样一个假设，即语言网络中的额颞叶连接中断是精神分裂症中形式思维障碍（FTD）的基础。纳入了 49 名精神分裂症谱系障碍患者（27 名轻度 FTD，22 名重度 FTD）和 26 名健康对照者（HC）。总体精神病学和 FTD 分别采用阳性和阴性综合征量表和思维、语言和沟通量表进行评估。使用基于束的空间统计学分析白质（WM）微观结构。在患者中，整体 FTD 的严重程度（TLC 总分）可由右侧上纵束（SLF）的分数各向异性（FA）降低来预测，而负性 FTD 的严重程度（TLC 空虚子量表）可由左侧 SLF 和弓状束（AF）的 FA 增加来预测。值得注意的是，在进行多次比较校正后，这些结果不再具有统计学意义。与 HC 相比，患者在所有研究的语言相关 WM 束以及整个 WM 骨架中均表现出 FA 值降低。重度 FTD 患者和轻度 FTD 患者之间的 FA 值无差异。我们的结果与先前的研究报告一致，即精神分裂症患者存在广泛的 WM 束损伤，包括与语言处理相关的 WM 束。
