Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Division of Endocrinology and Metabolism, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, ON M5G 2C4, Canada.
Int J Environ Res Public Health. 2018 May 26;15(6):1079. doi: 10.3390/ijerph15061079.
Women's hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected women aged 43⁻63 in the Canadian Multicentre Osteoporosis Study (CaM), a prospective Canada-wide study; we used linear regression to assess the relationship of night sweats (VMSn) with BMD and its changes. Clinically important VMSn occurred for 12.2%. Women with VMSn were slightly younger (54.5 vs. 55.3 years, = 0.02) and less likely to use sex steroid therapies (39.8% vs. 51.4%, < 0.05). BMD at the lumbar spine (L1-4), femoral neck (FN) and total hip (TH) were similar between those with/without VMSn. In adjusted models, we did not find a significant association between VMSn and 2-year change in L1-4, FN and TH BMD. Age, reproductive status, weight, sex steroid therapy and smoking status were associated with 2-year change in BMD. Incident fractures over 2 years also did not differ by VMSn. Our analyses were restricted to VMSn and may not truly capture the relationship between VMS and BMD. Additional research involving VMS, bone loss and fracture incidence is needed.
女性的热潮红和盗汗，统称为血管舒缩症状（VMS），在绝经后期最为严重（79%）。描述 VMS 是否与骨量减少有关的证据存在差异。我们检查了加拿大多中心骨质疏松症研究（CaM）中 1570 名随机选择的年龄在 43-63 岁的女性的基线和 2 年数据，这是一项前瞻性的加拿大全国性研究；我们使用线性回归来评估盗汗（VMSn）与 BMD 及其变化的关系。临床上重要的 VMSn 发生率为 12.2%。有 VMSn 的女性年龄稍小（54.5 岁 vs. 55.3 岁， = 0.02），使用性激素治疗的可能性较低（39.8% vs. 51.4%， < 0.05）。L1-4、股骨颈（FN）和全髋（TH）的 BMD 在有/无 VMSn 的女性之间相似。在调整后的模型中，我们没有发现 VMSn 与 L1-4、FN 和 TH BMD 的 2 年变化之间存在显著关联。年龄、生育状况、体重、性激素治疗和吸烟状况与 BMD 的 2 年变化有关。2 年内的骨折发生率也不因 VMSn 而不同。我们的分析仅限于 VMSn，可能无法真实反映 VMS 与 BMD 之间的关系。需要进一步研究 VMS、骨丢失和骨折发生率。
