Ryu Ki-Jin, Park Hyun-Tae, Kim Yong Jin, Yi Kyong Wook, Shin Jung Ho, Hur Jun Young, Kim Tak
Department of Obstetrics and Gynecology, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul 02841, South Korea.
Department of Obstetrics and Gynecology, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul 02841, South Korea.
Maturitas. 2016 May;87:27-32. doi: 10.1016/j.maturitas.2016.02.007. Epub 2016 Feb 12.
This study examined the relationships between vasomotor symptoms (VMS), bone mineral density (BMD) and osteoporosis in postmenopausal women.
A cross-sectional study was conducted of 1390 postmenopausal Korean women aged 45-65 years who attended a routine health check-up at a single institution. Their results on the Menopause Rating Scale were used to assess VMS, and moderate, severe, and very severe VMS were combined into moderate-to-severe VMS.
The relationships of VMS with BMD and osteoporosis in the lumbar spine and femoral neck bone were analyzed by multivariate regression analyses.
The mean age of all participants was 54.63 ± 4.78 years. Four hundred seventy-one (33.9%) women reported mild VMS and 344 (24.7%) reported moderate-to-severe VMS. Osteoporosis was newly diagnosed in 156 (11.2%) women. BMD levels were not significantly different among the no/mild/moderate-to-severe VMS groups, despite the significant differences in the prevalence of osteoporosis in the femoral neck bone. Women with mild VMS and those with moderate-to-severe VMS had a lower BMD than women without VMS after adjustment for age, years since menopause, years of reproductive age, BMI, insulin resistance, smoking, alcohol, steroids use, exercise, previous fracture and parental history of hip fracture. And moderate-to-severe VMS was significantly associated with the risk of osteoporosis in the femoral neck bone (OR = 2.97, 95% CI = 1.41-6.26) and in the lumbar spine (OR = 1.93, 95% CI = 1.09-3.40).
VMS are associated with decreased BMD, and moderate-to-severe VMS in particular are independently associated with the risk of osteoporosis in otherwise healthy postmenopausal Korean women.
本研究探讨绝经后女性血管舒缩症状（VMS）、骨矿物质密度（BMD）与骨质疏松症之间的关系。
对1390名年龄在45 - 65岁之间、在单一机构进行常规健康检查的韩国绝经后女性进行了横断面研究。她们的更年期评定量表结果用于评估VMS，中度、重度和极重度VMS合并为中度至重度VMS。
通过多因素回归分析，分析VMS与腰椎和股骨颈骨BMD及骨质疏松症之间的关系。
所有参与者的平均年龄为54.63±4.78岁。471名（33.9%）女性报告有轻度VMS，344名（24.7%）报告有中度至重度VMS。156名（11.2%）女性被新诊断为骨质疏松症。尽管股骨颈骨骨质疏松症患病率存在显著差异，但无/轻度/中度至重度VMS组之间的BMD水平无显著差异。在调整年龄、绝经年限、生育年龄、体重指数、胰岛素抵抗、吸烟、饮酒、使用类固醇、运动、既往骨折及髋部骨折家族史后，有轻度VMS的女性和有中度至重度VMS的女性的BMD低于无VMS的女性。中度至重度VMS与股骨颈骨（OR = 2.97，95% CI = 1.41 - 6.26）和腰椎（OR = 1.93，95% CI = 1.09 - 3.40）骨质疏松症风险显著相关。
VMS与BMD降低有关，尤其是中度至重度VMS与健康的韩国绝经后女性骨质疏松症风险独立相关。
