Li Fanjie, Du Yibin
Department of Orthopaedics, Third Affliated Hospital, Anhui Medical University, Hefei, Anhui, 230022, PR China.
J Orthop. 2020 Mar 28;22:53-58. doi: 10.1016/j.jor.2020.03.048. eCollection 2020 Nov-Dec.
This study was designed to establish bone mineral density (BMD) reference data of proximal femur, research the effect of age, height and weight on BMD of proximal femur, and estimate the prevalence of osteoporosis in a Chinese female population. In addition we compared the results with Lebanese and USA white women reference data.
Our study was conducted at one center, including 1578 Chinese women, aged 20-79years. We measured the BMD for proximal femur using dual-energy X-ray absorptiometry, and then established a reference database of proximal femur and set up regression equations of age, height and weight for BMD at proximal femur to research the effects of age, height and weight on BMD. After that, we calculated the standardized BMD and compared them with Lebanese and USA white women reference data.
The peak BMD occurred in the age range 30-39 years for femoral neck and Ward's triangle, and 40-49 years for trochanter in Chinese women, which were later than in Lebanese and USA white women. The BMD of proximal femur in Chinese women were lower than Lebanese and USA white women in most age ranges. Weight profoundly influenced BMD in all age groups, and age and height mainly effected BMD in older age groups. The standardized prevalence of osteoporosis among Chinese women of 50-79 years old was 9.6% in femoral neck, which was higher than Lebanese but lower than USA white women.
The BMD database of proximal femur in Chinese women we established is normative and different from Lebanese and USA white women reference data, which provides more reliable information on the prevalence of osteoporosis in China.
本研究旨在建立中国女性近端股骨骨密度（BMD）参考数据，研究年龄、身高和体重对近端股骨骨密度的影响，并评估中国女性人群骨质疏松症的患病率。此外，我们将结果与黎巴嫩和美国白人女性的参考数据进行了比较。
我们在一个中心开展了这项研究，纳入了1578名年龄在20 - 79岁的中国女性。我们使用双能X线吸收法测量近端股骨的骨密度，然后建立近端股骨参考数据库，并建立年龄、身高和体重与近端股骨骨密度的回归方程，以研究年龄、身高和体重对骨密度的影响。之后，我们计算标准化骨密度，并与黎巴嫩和美国白人女性的参考数据进行比较。
中国女性股骨颈和Ward三角骨密度峰值出现在30 - 39岁年龄段，大转子骨密度峰值出现在40 - 49岁年龄段，这比黎巴嫩和美国白人女性出现峰值的年龄要晚。在大多数年龄范围内，中国女性近端股骨的骨密度低于黎巴嫩和美国白人女性。体重对所有年龄组的骨密度都有显著影响，年龄和身高主要影响老年组的骨密度。50 - 79岁中国女性股骨颈骨质疏松症的标准化患病率为9.6%，高于黎巴嫩女性但低于美国白人女性。
我们建立的中国女性近端股骨骨密度数据库具有规范性，且与黎巴嫩和美国白人女性参考数据不同，为中国骨质疏松症患病率提供了更可靠的信息。
