横断面研究和健康幼儿随机试验中维生素 D 状态与免疫健康结局。
Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children.
机构信息
School of Human Nutrition, McGill University, 21111 Lakeshore Rd, Ste-Anne-de-Bellevue, Montreal, QC H9X 3V9, Canada.
Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-126a Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2E1, Canada.
出版信息
Nutrients. 2018 May 27;10(6):680. doi: 10.3390/nu10060680.
In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years ( = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old ( = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: = 242; 53%), plasma IL-6, TNFα and CRP were significantly higher ( < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.
在幼儿中，维生素 D 与免疫功能生物标志物之间的关系尚未得到充分阐明。本研究旨在探究维生素 D 与幼儿免疫功能之间的关系。研究数据来自于一项横断面研究（研究 1），共纳入了 457 名健康 1.8-5.9 岁的儿童；以及一项为期 12 周的试验（研究 2），共纳入了 77 名健康 1.8-8.7 岁的儿童，均来自加拿大的蒙特利尔。本研究评估了儿童的维生素 D 状态和体外免疫功能。在研究 1 中（男性： = 242；占比 53%），25-羟维生素 D（25(OH)D）≥75nmol/L 的儿童的血浆白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNFα）和 C 反应蛋白（CRP）显著更高（ < 0.05）。
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