Morikawa E, Mudau M, Olivier D, de Vos L, Joseph Davey D, Price C, McIntyre J A, Peters R P, Klausner J D, Medina-Marino A
Division of Infectious Disease, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Research Unit, Foundation for Professional Development, Pretoria, South Africa.
Infect Dis Obstet Gynecol. 2018 May 9;2018:3946862. doi: 10.1155/2018/3946862. eCollection 2018.
, , and (TV) infections may increase the risk of vertical transmission of the human immunodeficiency virus (HIV). In resource-limited settings, symptomatic screening, and syndromic management of sexually transmitted infections (STIs) during pregnancy continue to be the standard of care. In the absence of diagnostic testing, asymptomatic infections in pregnant women go untreated.
To describe the acceptability and feasibility of integrating diagnostic STI screening into first antenatal care visits for HIV-infected pregnant women.
HIV-infected pregnant women were recruited during their first antenatal care visit from three antenatal care clinics in Tshwane District, South Africa, between June 2016 and October 2017. Self-collected vaginal swabs were used to screen for CT, NG, and TV with a diagnostic point-of-care (POC) nucleic acid amplification test. Those with STIs were provided treatment per South African national guidelines.
Of 442 eligible women, 430 (97.3%) agreed to participate and were tested. Of those with a positive STI test result ( = 173; 40.2%), 159 (91.9%) received same-day results and treatment; 100% of STI-infected women were treated within seven days.
Integration of POC diagnostic STI screening into first-visit antenatal care services was feasible and highly acceptable for HIV-infected pregnant women.
沙眼衣原体（CT）、淋病奈瑟菌（NG）和滴虫（TV）感染可能会增加人类免疫缺陷病毒（HIV）垂直传播的风险。在资源有限的环境中，孕期性传播感染（STIs）的症状性筛查和综合征管理仍然是标准的治疗方法。在缺乏诊断检测的情况下，孕妇的无症状感染得不到治疗。
描述将性传播感染诊断性筛查纳入HIV感染孕妇首次产前检查的可接受性和可行性。
2016年6月至2017年10月期间，从南非茨瓦内区的三家产前检查诊所招募HIV感染孕妇，在她们首次产前检查时进行研究。使用自我采集的阴道拭子，通过即时诊断（POC）核酸扩增试验筛查CT、NG和TV。根据南非国家指南为患有性传播感染的孕妇提供治疗。
在442名符合条件的女性中，430名（97.3%）同意参与并接受检测。在性传播感染检测结果呈阳性的女性中（n = 173；40.2%），159名（91.9%）在当天获得了检测结果并接受了治疗；100%的性传播感染感染女性在七天内接受了治疗。
将POC诊断性性传播感染筛查纳入首次产前检查服务对HIV感染孕妇来说是可行的，并且非常容易接受。
