Foundation for Professional Development, Research Unit, East London, South Africa.
Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
Int J STD AIDS. 2021 Aug;32(9):799-805. doi: 10.1177/0956462421990218. Epub 2021 Mar 26.
Sexually transmitted infections (STIs) can be transmitted from mother to neonate. We determined the frequency of mother-to-child transmission (MTCT) of , , and to the newborn nasopharynx.
This study was nested in a cohort study of etiologic testing versus syndromic management for STIs among pregnant women living with human immunodeficiency virus in South Africa. Mothers were tested for STIs using the GeneXpert platform within 60 days after delivery. Nasopharyngeal swabs were obtained from newborns of mothers with a positive STI test; these were then tested by Xpert® on the same day based on the maternal STI diagnosis.
We tested nasopharyngeal swabs from 85 STI-exposed newborns; 74 (87%) were tested within 2 weeks after birth (median five; range 2-12 days). MTCT frequency of any STI was 30/74 (41%); 43% (23/53) for , 29% (2/7) for , and 24% (6/25) for . Also, 4/11 (36%) swabs obtained between 14 and 60 days after delivery tested positive for STI.
There was a high frequency of MTCT of STIs to the nasopharynx of newborns in our setting. The impact of nasopharyngeal colonization and the benefits of STI testing on newborn health remain to be determined.
性传播感染（STI）可从母亲传播给新生儿。我们确定了 、 、 向新生儿鼻咽部传播的母婴传播（MTCT）频率。
本研究嵌套在南非一项针对人类免疫缺陷病毒感染孕妇的病因学检测与综合征管理的队列研究中。母亲在分娩后 60 天内使用 GeneXpert 平台检测 STI。对母亲 STI 检测阳性的新生儿采集鼻咽拭子；根据母体 STI 诊断，当天在 Xpert®上对这些拭子进行检测。
我们测试了 85 名 STI 暴露新生儿的鼻咽拭子；74 名（87%）在出生后 2 周内进行了检测（中位数为 5 天；范围 2-12 天）。任何 STI 的 MTCT 频率为 30/74（41%）； 、 、 分别为 43%（23/53）、29%（2/7）和 24%（6/25）。此外，14-60 天产后采集的 4/11（36%）拭子 STI 检测阳性。
在我们的研究环境中，STI 向新生儿鼻咽部传播的频率很高。鼻咽部定植的影响以及 STI 检测对新生儿健康的益处仍有待确定。
