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胶原蛋白-聚己内酯纳米纤维基质涂层对钛的细胞相容性和骨反应的影响

Effect of Collagen-Polycaprolactone Nanofibers Matrix Coating on the Cytocompatibility and Bone Responses of Titanium.

作者信息

Khandaker Morshed, Riahinezhad Shahram, Sultana Fariha, Morris Tracy, Wolf Roman, Vaughan Melville

机构信息

Department of Engineering & Physics, University of Central Oklahoma, Edmond, Oklahoma 73034, USA.

Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, Oklahoma, 73034, USA.

出版信息

J Med Biol Eng. 2018 Apr;38(2):197-210. doi: 10.1007/s40846-017-0312-7. Epub 2017 Jul 24.

DOI:10.1007/s40846-017-0312-7
PMID:29861706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5977393/
Abstract

The objective of this study was to improve the biomechanical performance of titanium (Ti) using a biocompatible electrospun nanofiber matrix. The study is based on the hypothesis that coating a Ti surface with a nanofiber matrix (NFM) made of collagen (CG) and polycaprolactone (PCL) electrospun nanofibers could increase the mechanical fixation of Ti/bone by improving the surface and cytocompatibility properties of Ti. This study prepared Ti samples with and without CG-PCL NFM coatings. This study determined the effects of each group of Ti samples on the surface topography and cytocompatibility (osteoblast cell adhesion, proliferation, mineralization and protein adsorption) properties. This study also determined interface shear strength and bone volume fraction of each group of Ti samples with bone using a rabbit model. This study found that the CG-PCL NFM coating on Ti improved the surface roughness, osteoblast cell adhesion, proliferation, mineralization and protein adsorption properties of Ti. studies found that interface shear strength of CG-PCL NFM-coated Ti/bone samples was significantly higher compared to those values of control Ti/bone samples ( value < 0.05) due to an increase in the amount of growth of the connective tissue joining the Ti implant. Therefore, the developed CG-PCL NFM coating technique should further be investigated for its potential in clinical applications.

摘要

本研究的目的是使用具有生物相容性的电纺纳米纤维基质来改善钛（Ti）的生物力学性能。该研究基于这样的假设：用由胶原蛋白（CG）和聚己内酯（PCL）电纺纳米纤维制成的纳米纤维基质（NFM）涂覆Ti表面，可以通过改善Ti的表面和细胞相容性特性来增加Ti/骨的机械固定。本研究制备了有和没有CG-PCL NFM涂层的Ti样品。本研究确定了每组Ti样品对表面形貌和细胞相容性（成骨细胞粘附、增殖、矿化和蛋白质吸附）特性的影响。本研究还使用兔模型确定了每组Ti样品与骨的界面剪切强度和骨体积分数。本研究发现，Ti上的CG-PCL NFM涂层改善了Ti的表面粗糙度、成骨细胞粘附、增殖、矿化和蛋白质吸附特性。研究发现，由于连接Ti植入物的结缔组织生长量增加，CG-PCL NFM涂层的Ti/骨样品的界面剪切强度明显高于对照Ti/骨样品的值（P值<0.05）。因此，应进一步研究开发的CG-PCL NFM涂层技术在临床应用中的潜力。

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