用于铜介导的叠氮化物-炔烃点击环加成反应的扩环N-杂环卡宾
Ring-Expanded N-Heterocyclic Carbenes for Copper-Mediated Azide-Alkyne Click Cycloaddition Reactions.
作者信息
Sebest Filip, Dunsford Jay J, Adams Matthew, Pivot Jeremy, Newman Paul D, Díez-González Silvia
机构信息
Department of Chemistry Imperial College London Exhibition Road, South Kensington London SW7 2AZ UK.
School of Chemistry Cardiff University Cardiff CF10 3AT UK.
出版信息
ChemCatChem. 2018 May 9;10(9):2041-2045. doi: 10.1002/cctc.201701992. Epub 2018 Mar 7.
A series of well-defined copper(I) complexes bearing ring-expanded N-heterocyclic carbene (NHC) ligands has been applied to the azide-alkyne cycloaddition reaction. The obtained results notably showed that the six-membered NHC ligands outperform well-established five-membered ones. [CuI(Mes-6)] displayed a remarkable catalytic activity while respecting the strict criteria for click reactions.
一系列带有扩环N-杂环卡宾（NHC）配体的结构明确的铜（I）配合物已被应用于叠氮化物-炔烃环加成反应。所得结果显著表明，六元NHC配体的性能优于已确立的五元配体。[CuI（Mes-6）]在符合点击反应严格标准的同时表现出显著的催化活性。
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