一种由“超级硅基”控制的高度非对映选择性羟醛反应：α,β-二氧醛和1,2,3-三醇的合成。

Gati Wafa, Yamamoto Hisashi

Molecular Catalyst Research Center , Chubu University , 1200 Matsumoto-cho , Kasugai , Aichi 487-8501 , Japan . Email:

Chem Sci. 2016 Jan 1;7(1):394-399. doi: 10.1039/c5sc03307a. Epub 2015 Oct 6.

A highly diastereoselective approach for the synthesis of protected α,β-dioxyaldehydes derived from ()-tris(trimethylsilyl)silyl "super silyl" enol ethers is described. A general and highly -stereoselective aldol reaction directed by the "super silyl" group catalyzed by triflimide (HNTf) is developed providing α,β-dioxyaldehydes and 1,2,3-triol fragments which can be a useful platform for the elaboration of natural and unnatural sugar derivatives.

本文描述了一种从（）-三（三甲基硅基）硅基“超级硅基”烯醇醚合成受保护的α，β-二氧醛的高非对映选择性方法。开发了一种由三氟甲磺酸亚胺（HNTf）催化的、由“超级硅基”基团导向的通用且高立体选择性的羟醛反应，可提供α，β-二氧醛和1,2,3-三醇片段，这些片段可为天然和非天然糖衍生物的合成提供有用的平台。