Jutzy Jessica M S, Lemons Jeffrey M, Luke Jason J, Chmura Steven J
Department of Radiation Oncology, University of Chicago, Chicago, IL, USA.
Department of Medicine, University of Chicago, Chicago, IL, USA.
Int J Breast Cancer. 2018 May 16;2018:4786819. doi: 10.1155/2018/4786819. eCollection 2018.
Radiation therapy is a mainstay of treatment in early and locally advanced breast cancer but is typically reserved for palliation of symptomatic lesions in patients with metastatic breast cancer. With new advances in the field of tumor biology and immunology, the role of radiation in the metastatic setting is evolving to harness its immune-enhancing properties. Through the release of tumor antigens, tumor DNA, and cytokines into the tumor microenvironment, radiation augments the antitumoral immune response to affect both the targeted lesion and distant sites of metastatic disease. The use of immunotherapeutics to promote antitumoral immunity has resulted in improved treatment responses in patients with metastatic disease and the combination of radiation therapy and immunotherapy has become an area of intense investigation. In this article, we will review the emerging role of radiation in the treatment of metastatic disease and discuss the current state of the science and clinical trials investigating the combination of radiation and immunotherapy.
放射治疗是早期和局部晚期乳腺癌治疗的主要手段，但通常仅用于转移性乳腺癌有症状病灶的姑息治疗。随着肿瘤生物学和免疫学领域的新进展，放射治疗在转移性疾病中的作用正在演变，以利用其免疫增强特性。通过将肿瘤抗原、肿瘤DNA和细胞因子释放到肿瘤微环境中，放射治疗增强抗肿瘤免疫反应，从而影响靶向病灶和转移性疾病的远处部位。使用免疫疗法促进抗肿瘤免疫已使转移性疾病患者的治疗反应得到改善，放射治疗与免疫治疗的联合应用已成为一个深入研究的领域。在本文中，我们将综述放射治疗在转移性疾病治疗中的新作用，并讨论研究放射治疗与免疫治疗联合应用的科学现状和临床试验情况。
