Harris Eleanor E R
Department of Radiation Oncology, Case Western Reserve University and University Hospitals, Cleveland, OH, USA.
Int J Breast Cancer. 2018 May 9;2018:4809183. doi: 10.1155/2018/4809183. eCollection 2018.
Precision medicine in oncology seeks to individualize each patient's treatment regimen based on an accurate assessment of the risk of recurrence or progression of that person's cancer. Precision will be achieved at each phase of care, from detection to diagnosis to surgery, systemic therapy, and radiation therapy, to survivorship and follow-up care. The precision arises from detailed knowledge of the inherent biological propensities of each tumor, rather than generalizing treatment approaches based on phenotypic, or even genotypic, categories. Extensive research is being conducted in multiple disciplines, including radiology, pathology, molecular biology, and surgical, medical, and radiation oncology. Clinical trial design is adapting to the new paradigms and moving away from grouping heterogeneous patient populations into limited treatment comparison arms. This review touches on several areas invested in clinical research. This special issue highlights the specific work of a number of groups working on precision medicine for breast cancer.
肿瘤学中的精准医学旨在基于对个体癌症复发或进展风险的准确评估，为每位患者制定个性化的治疗方案。在从检测到诊断、手术、全身治疗、放射治疗，再到生存及后续护理的每个护理阶段都将实现精准。这种精准源于对每个肿瘤固有生物学倾向的详细了解，而非基于表型甚至基因型类别来归纳治疗方法。包括放射学、病理学、分子生物学以及外科、医学和放射肿瘤学在内的多个学科都在进行广泛研究。临床试验设计正在适应新的模式，不再将异质性患者群体归入有限的治疗比较组。本综述涉及临床研究的多个领域。本期特刊重点介绍了多个致力于乳腺癌精准医学研究的团队的具体工作。
