Department of Neurosurgery, Sainte-Anne Hospital, 1 rue Cabanis, 75674 Paris Cedex 14, France.
Ann Neurol. 2010 Mar;67(3):398-404. doi: 10.1002/ana.21888.
Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.
11 例成年女性在妊娠前患有世界卫生组织（WHO）Ⅱ级胶质瘤（GIIG），回顾性分析妊娠前后连续磁共振图像上直径扩张的放射学速度（VDE），以探讨妊娠是否影响肿瘤生长。与妊娠前（p<0.001）和产后（p=0.012）相比，妊娠期间 VDE 显著增加。妊娠增加了 GIIG 的影像学生长速度。40%的病例同时观察到癫痫发作频率增加，25%的病例在分娩后开始进行进一步的肿瘤治疗。
