电休克治疗后紧张型精神分裂症患者唾液α-淀粉酶活性水平降低。
Salivary Alpha-Amylase Activity Levels in Catatonic Schizophrenia Decrease after Electroconvulsive Therapy.
作者信息
Kanayama Misako, Miyaoka Tsuyoshi, Araki Tomoko, Hayashida Maiko, Hashioka Sadayuki, Horiguchi Jun
机构信息
Department of Psychiatry, Shimane University of Medicine, 89-1 Enyacho, Izumo 6938501, Japan.
出版信息
Case Rep Psychiatry. 2018 May 10;2018:2623585. doi: 10.1155/2018/2623585. eCollection 2018.
BACKGROUND
Dysfunction of the autonomic nervous system (ANS) in schizophrenia has been detected by electrophysiological methods, but the underlying mechanisms remain unknown. Several studies have suggested that measuring salivary alpha-amylase activity levels is useful for evaluating the ANS activity and that sAA levels increase in schizophrenia and correlate with Brief Psychiatric Rating Scale (BPRS) scores. However, no study has examined the relationship between sAA activity levels and symptoms of schizophrenia with catatonic state.
METHODS
We present the case of a 59-year-old female with persistent catatonic schizophrenia treated by electroconvulsive therapy. We evaluated the ANS activity by measuring sAA activity levels before and after ECT, and we evaluated her symptoms using the BPRS and Bush-Francis Catatonia Rating Scale (BFCRS).
RESULTS
ECT was highly effective and BPRS and BFCRS scores substantially decreased. sAA activity levels decreased from 125 kU/l to 33 kU/l.
CONCLUSIONS
sAA activity levels could be a potential biomarker of schizophrenia with catatonic state.
背景
精神分裂症患者自主神经系统（ANS）功能障碍已通过电生理方法检测到，但其潜在机制仍不清楚。多项研究表明，测量唾液α-淀粉酶活性水平有助于评估自主神经系统活动，且精神分裂症患者唾液α-淀粉酶（sAA）水平升高，并与简明精神病评定量表（BPRS）评分相关。然而，尚无研究探讨sAA活性水平与紧张症状态的精神分裂症症状之间的关系。
方法
我们报告了1例接受电休克治疗的59岁持续性紧张型精神分裂症女性患者的病例。我们通过测量电休克治疗前后的sAA活性水平来评估自主神经系统活动，并使用BPRS和布什-弗朗西斯紧张症评定量表（BFCRS）评估其症状。
结果
电休克治疗非常有效，BPRS和BFCRS评分大幅下降。sAA活性水平从125 kU/l降至33 kU/l。
结论
sAA活性水平可能是紧张症状态精神分裂症的潜在生物标志物。
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