翼状胬肉治疗的当前方法与未来方向
Current approaches and future directions in the management of pterygium.
作者信息
Kim Kyoung Woo, Kim Jae Chan
机构信息
Graduate School of Chung-Ang University, College of Medicine, Seoul 156-755, Republic of Korea.
Department of Ophthalmology, College of Medicine, Chung-Ang University Hospital, Seoul 156-755, Republic of Korea.
出版信息
Int J Ophthalmol. 2018 May 18;11(5):709-711. doi: 10.18240/ijo.2018.05.01. eCollection 2018.
Abstract
Pterygium, a common ocular surface disorder, has a complex pathophysiology that may mimic tumorigenesis. There is altered expression of cell cycle/proliferation-related factors in pterygium tissues. Therefore, similar to cancer treatments, the management of pterygium ought to be multifactorial based on the patient's condition. Current therapeutic methods for pterygium are focused on surgical resection in conjunction with antimetabolite use, in addition tissue graft is usually performed in the context of the avoidance of bare sclera. However, future directions in the management of pterygia will likely focus on genetic approaches. This perspective views the pathogenesis of pterygium, its existing therapies as well as current and future challenges in its treatment.
摘要
翼状胬肉是一种常见的眼表疾病，其病理生理过程复杂，可能类似于肿瘤发生。翼状胬肉组织中细胞周期/增殖相关因子的表达发生改变。因此，与癌症治疗类似，翼状胬肉的治疗应根据患者的病情采取多因素方法。目前翼状胬肉的治疗方法主要集中在手术切除并联合使用抗代谢药物，此外，通常在避免裸巩膜的情况下进行组织移植。然而，翼状胬肉治疗的未来方向可能会集中在基因治疗方法上。本文阐述了翼状胬肉的发病机制、现有的治疗方法以及其治疗中当前和未来面临的挑战。
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