Ahmadi Somayeh, Radahmadi Maryam, Alaei Hojjatallah, Ramshini Effat
Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran.
Adv Biomed Res. 2018 Apr 24;7:70. doi: 10.4103/abr.abr_181_17. eCollection 2018.
Exercise reverses retention deficit induced by morphine. The present study investigated the effect of aerobic exercise on tolerance to morphine usage and pain modulation.
Male Wistar rats were divided into four groups as follows: (1) saline group (S), (2) morphine group (M), (3) saline + exercise (S + E), and (4) morphine + exercise group (M + E). The rats were initially trained to receive small pellets of food by pressing an active lever in the self-administration apparatus. The tail-flick and hot-plate tests were used for pain assessment. To perform the experiment, the jugular vein was exposed and cannulated. After recovery, the animals were placed in the self-administration apparatus and allowed to self-administer morphine in 2 h sessions over 11 consecutive days.
The morphine group was found to record a higher number of active lever pressings than did the saline one while this parameter decreased in the morphine + exercise group compared with the morphine one. Moreover, the morphine + exercise exhibited lowered pain sensitivity as evidenced to have reduced morphine use in the hot plate test.
The exercise might be suggested to reduce using of morphine and modulate pain probably through the release of endogenous opioid.
运动可逆转吗啡诱导的记忆缺陷。本研究调查了有氧运动对吗啡使用耐受性和疼痛调节的影响。
雄性Wistar大鼠分为四组如下：（1）生理盐水组（S），（2）吗啡组（M），（3）生理盐水+运动组（S+E），以及（4）吗啡+运动组（M+E）。大鼠最初通过按压自我给药装置中的活动杠杆来接受小颗粒食物进行训练。采用甩尾和热板试验进行疼痛评估。为进行实验，暴露并插管颈静脉。恢复后，将动物置于自我给药装置中，连续11天每天进行2小时的吗啡自我给药。
发现吗啡组的活动杠杆按压次数高于生理盐水组，而与吗啡组相比，吗啡+运动组的该参数有所下降。此外，吗啡+运动组表现出较低的疼痛敏感性，热板试验表明其吗啡使用量减少。
运动可能通过内源性阿片类物质的释放来减少吗啡的使用并调节疼痛。
