Ruprecht-Karls Universität Heidelberg, Anorganisch-Chemisches Institut and Interdisciplinary Center for Scientific Computing (IWR), Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Dalton Trans. 2018 Jul 17;47(28):9202-9220. doi: 10.1039/c8dt01108g.
Very rigid tetra-, penta-, hexa-, hepta- and octadentate bispidine ligands are well preorganized for specific coordination geometries. The broad range of coordination numbers, geometries and donor sets allows one to design and prepare bispidines for many specific metal ions and applications. Major requirements for radiopharmaceuticals are efficient labeling, inertness under physiological conditions and easy functionalization of the ligands with biological vectors. The reasons why bispidines are among the most favorable chelators for radiopharmaceutical applications, a comprehensive list of bispidine ligands and a range of examples where bispidines have been used to develop radiopharmaceuticals for future applications in diagnosis and therapy are discussed.
非常刚性的四齿、五齿、六齿、七齿和八齿双吡啶配体对于特定的配位几何形状具有很好的预组织性。广泛的配位数、几何形状和供体集允许设计和制备双吡啶配体以用于许多特定的金属离子和应用。放射性药物的主要要求是高效标记、在生理条件下的惰性和生物载体的配体的易于功能化。双吡啶配体是放射性药物应用中最有利的螯合剂之一的原因，讨论了双吡啶配体的综合清单以及双吡啶用于开发放射性药物以用于未来诊断和治疗应用的一系列示例。
