• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于核与荧光分子成像的双标记策略：现状与未来展望

Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives.

作者信息

Kubeil Manja, Martínez Irma Ivette Santana, Bachmann Michael, Kopka Klaus, Tuck Kellie L, Stephan Holger

机构信息

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.

National Center for Tumor Diseases (NCT) Dresden, University Hospital Carl Gustav Carus, Fetscherstraße 74, 01307 Dresden, Germany.

出版信息

Pharmaceuticals (Basel). 2022 Mar 31;15(4):432. doi: 10.3390/ph15040432.

DOI:10.3390/ph15040432
PMID:35455430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9028399/
Abstract

Molecular imaging offers the possibility to investigate biological and biochemical processes non-invasively and to obtain information on both anatomy and dysfunctions. Based on the data obtained, a fundamental understanding of various disease processes can be derived and treatment strategies can be planned. In this context, methods that combine several modalities in one probe are increasingly being used. Due to the comparably high sensitivity and provided complementary information, the combination of nuclear and optical probes has taken on a special significance. In this review article, dual-labelled systems for bimodal nuclear and optical imaging based on both modular ligands and nanomaterials are discussed. Particular attention is paid to radiometal-labelled molecules for single-photon emission computed tomography (SPECT) and positron emission tomography (PET) and metal complexes combined with fluorescent dyes for optical imaging. The clinical potential of such probes, especially for fluorescence-guided surgery, is assessed.

摘要

分子成像提供了非侵入性研究生物和生化过程以及获取解剖结构和功能障碍信息的可能性。基于所获得的数据，可以对各种疾病过程有基本的了解，并制定治疗策略。在这种情况下，将多种模态结合在一个探针中的方法越来越多地被使用。由于具有相对较高的灵敏度并能提供互补信息，核探针与光学探针的结合具有特殊意义。在这篇综述文章中，讨论了基于模块化配体和纳米材料的用于双模态核成像和光学成像的双标记系统。特别关注用于单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）的放射性金属标记分子以及与荧光染料结合用于光学成像的金属配合物。评估了此类探针的临床潜力，特别是在荧光引导手术方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/51d5fad54a7a/pharmaceuticals-15-00432-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/5ff9186cd74a/pharmaceuticals-15-00432-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/ce9193ee4bdb/pharmaceuticals-15-00432-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/3734884f9d97/pharmaceuticals-15-00432-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/99614ae7733b/pharmaceuticals-15-00432-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/d3369e4b159f/pharmaceuticals-15-00432-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/17fcd13e54c0/pharmaceuticals-15-00432-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/70f886c5674b/pharmaceuticals-15-00432-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/08bccbc04232/pharmaceuticals-15-00432-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/541d83f6f607/pharmaceuticals-15-00432-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/3411e56122c3/pharmaceuticals-15-00432-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/2e8a6c11901b/pharmaceuticals-15-00432-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/b428c8e21e0b/pharmaceuticals-15-00432-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/8b13109c2987/pharmaceuticals-15-00432-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/51d5fad54a7a/pharmaceuticals-15-00432-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/5ff9186cd74a/pharmaceuticals-15-00432-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/ce9193ee4bdb/pharmaceuticals-15-00432-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/3734884f9d97/pharmaceuticals-15-00432-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/99614ae7733b/pharmaceuticals-15-00432-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/d3369e4b159f/pharmaceuticals-15-00432-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/17fcd13e54c0/pharmaceuticals-15-00432-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/70f886c5674b/pharmaceuticals-15-00432-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/08bccbc04232/pharmaceuticals-15-00432-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/541d83f6f607/pharmaceuticals-15-00432-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/3411e56122c3/pharmaceuticals-15-00432-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/2e8a6c11901b/pharmaceuticals-15-00432-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/b428c8e21e0b/pharmaceuticals-15-00432-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/8b13109c2987/pharmaceuticals-15-00432-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c721/9028399/51d5fad54a7a/pharmaceuticals-15-00432-g014.jpg

相似文献

1
Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives.用于核与荧光分子成像的双标记策略：现状与未来展望
Pharmaceuticals (Basel). 2022 Mar 31;15(4):432. doi: 10.3390/ph15040432.
2
Nuclear and optical dual-labelled imaging agents. Design and challenges.核与光学双标记成像剂。设计与挑战。
Nuklearmedizin. 2016;55(2):41-50.
3
Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis.双标记策略在核与荧光分子影像中的应用：综述与分析。
Mol Imaging Biol. 2012 Jun;14(3):261-76. doi: 10.1007/s11307-011-0528-9.
4
Recent developments in multimodality fluorescence imaging probes.多模态荧光成像探针的最新进展。
Acta Pharm Sin B. 2018 May;8(3):320-338. doi: 10.1016/j.apsb.2018.03.010. Epub 2018 Mar 30.
5
[Biomedical imaging in pharmacology with nuclear medical imaging methodologies: positron emission tomography (PET) and single photon emission computed tomography (SPECT)].药理学中的生物医学成像与核医学成像方法：正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）
Nihon Yakurigaku Zasshi. 2003 Mar;121(3):181-91. doi: 10.1254/fpj.121.181.
6
In Vivo Molecular Imaging.体内分子成像
Biol Pharm Bull. 2017;40(10):1605-1615. doi: 10.1248/bpb.b17-00505.
7
Nuclear and Optical Bimodal Imaging Probes Using Sequential Assembly: A Perspective.基于顺序组装的核-光双模成像探针：观点。
Cancer Biother Radiopharm. 2018 Oct;33(8):308-315. doi: 10.1089/cbr.2018.2499. Epub 2018 Jul 13.
8
Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease.用于阿尔茨海默病中淀粉样斑块成像的近红外荧光探针。
Acta Pharm Sin B. 2015 Jan;5(1):25-33. doi: 10.1016/j.apsb.2014.12.006. Epub 2015 Jan 2.
9
Radioactive Nanomaterials for Multimodality Imaging.用于多模态成像的放射性纳米材料
Tomography. 2016 Mar;2(1):3-16. doi: 10.18383/j.tom.2016.00121.
10
Recent advances in nuclear and hybrid detection modalities for image-guided surgery.核医学与杂交影像引导手术检测技术的最新进展。
Expert Rev Med Devices. 2019 Aug;16(8):711-734. doi: 10.1080/17434440.2019.1642104. Epub 2019 Jul 26.

引用本文的文献

1
Dual-imaging nanoparticles based on surface-modified magnetic nanoparticles and biodegradable photoluminescent polymers.基于表面改性磁性纳米颗粒和可生物降解光致发光聚合物的双成像纳米颗粒。
Front Bioeng Biotechnol. 2025 Apr 10;13:1558817. doi: 10.3389/fbioe.2025.1558817. eCollection 2025.
2
Metal Complexes of Bispidine Derivatives: Achievements and Prospects for the Future.联吡啶衍生物的金属配合物：成就与未来展望
Molecules. 2025 Mar 3;30(5):1138. doi: 10.3390/molecules30051138.
3
Current status and future prospects of molecular imaging in targeting the tumor immune microenvironment.

本文引用的文献

1
Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.用于PET/MRI/光学成像的诊疗一体化AGuIX®纳米颗粒的功能化
RSC Adv. 2019 Aug 9;9(43):24811-24815. doi: 10.1039/c9ra00365g. eCollection 2019 Aug 8.
2
Metal ion size profoundly affects Hglyox chelate chemistry.金属离子大小对乙二醛合汞螯合物化学有深远影响。
RSC Adv. 2021 Apr 27;11(26):15663-15674. doi: 10.1039/d1ra01793d. eCollection 2021 Apr 26.
3
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy.一种用于协同化学-光热治疗的近红外二区 Ru(II) 多吡啶配合物。
分子成像在靶向肿瘤免疫微环境中的现状与未来前景
Front Immunol. 2025 Jan 22;16:1518555. doi: 10.3389/fimmu.2025.1518555. eCollection 2025.
4
Comparison of Two Chelator Scaffolds as Basis for Cholecystokinin-2 Receptor Targeting Bimodal Imaging Probes.两种螯合剂支架作为靶向胆囊收缩素-2受体的双模态成像探针基础的比较
Pharmaceuticals (Basel). 2024 Nov 22;17(12):1569. doi: 10.3390/ph17121569.
5
Surgical radioguidance with beta-emitting radionuclides; challenges and possibilities: A position paper by the EANM.β发射放射性核素的外科放射引导：挑战与可能：EANM 立场文件。
Eur J Nucl Med Mol Imaging. 2024 Aug;51(10):2903-2921. doi: 10.1007/s00259-023-06560-2. Epub 2024 Jan 8.
6
Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents.探索纳米凝胶的潜力：从药物载体到放射药物制剂。
Adv Healthc Mater. 2024 Jan;13(1):e2301404. doi: 10.1002/adhm.202301404. Epub 2023 Sep 28.
7
Pre- and Intraoperative Visualization of GRPR-Expressing Solid Tumors: Preclinical Profiling of Novel Dual-Modality Probes for Nuclear and Fluorescence Imaging.表达胃泌素释放肽受体的实体瘤的术前和术中可视化：用于核成像和荧光成像的新型双模态探针的临床前分析
Cancers (Basel). 2023 Apr 5;15(7):2161. doi: 10.3390/cancers15072161.
J Med Chem. 2022 Feb 10;65(3):2225-2237. doi: 10.1021/acs.jmedchem.1c01736. Epub 2022 Jan 7.
4
PET/Fluorescence Imaging: An Overview of the Chemical Strategies to Build Dual Imaging Tools.正电子发射断层扫描/荧光成像：构建双模式成像工具的化学策略概述。
Bioconjug Chem. 2022 Jan 19;33(1):24-52. doi: 10.1021/acs.bioconjchem.1c00503. Epub 2022 Jan 7.
5
Strain-Promoted Azide-Alkyne Cycloaddition-Based PSMA-Targeting Ligands for Multimodal Intraoperative Tumor Detection of Prostate Cancer.基于应变促进的叠氮-炔环加成的 PSMA 靶向配体用于前列腺癌的多模态术中肿瘤检测。
Bioconjug Chem. 2022 Jan 19;33(1):194-205. doi: 10.1021/acs.bioconjchem.1c00537. Epub 2021 Dec 25.
6
Radiolabeled Silicon-Rhodamines as Bimodal PET/SPECT-NIR Imaging Agents.放射性标记的硅罗丹明作为双模态PET/SPECT-近红外成像剂
Pharmaceuticals (Basel). 2021 Nov 12;14(11):1155. doi: 10.3390/ph14111155.
7
[Zr][Zr(pypa)]: Thermodynamically Stable and Kinetically Inert Binary Nonadentate Complex for Radiopharmaceutical Applications.[Zr][Zr(pypa)]：用于放射性药物应用的热力学稳定和动力学惰性的二元非齿状配合物。
Inorg Chem. 2021 Dec 6;60(23):18082-18093. doi: 10.1021/acs.inorgchem.1c02709. Epub 2021 Nov 17.
8
Molecular Probes for Autofluorescence-Free Optical Imaging.用于无自发荧光光学成像的分子探针。
Chem Rev. 2021 Nov 10;121(21):13086-13131. doi: 10.1021/acs.chemrev.1c00506. Epub 2021 Sep 24.
9
Hpyhox - Octadentate Bis(pyridyloxine).羟嗪 - 八齿双（吡啶并恶嗪）。
Inorg Chem. 2021 Aug 16;60(16):12186-12196. doi: 10.1021/acs.inorgchem.1c01412. Epub 2021 Jul 26.
10
Advances in anion binding and sensing using luminescent lanthanide complexes.基于发光镧系配合物的阴离子结合与传感研究进展
Chem Sci. 2021 Jan 26;12(8):2716-2734. doi: 10.1039/d0sc05419d.