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联吡啶中的旋转运动：构象研究。

Rotational Motion in Bispidines: A Conformational Study.

作者信息

Migliano Francesco, Pozzi Luca, Citarella Andrea, Macetti Giovanni, Lo Presti Leonardo, Passarella Daniele, Fasano Valerio

机构信息

Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.

出版信息

Org Lett. 2025 Sep 5;27(35):9669-9673. doi: 10.1021/acs.orglett.5c02839. Epub 2025 Aug 26.

DOI:10.1021/acs.orglett.5c02839
PMID:40857087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12418502/
Abstract

A detailed conformational analysis of -substituted bispidines has been performed to determine the factors governing the restricted rotational motion induced by the substituents. This investigation combines computational studies of the transition state involved in the rotation with experimental characterization of the rotamers arising from the restricted rotation.

摘要

已对β-取代的双吡啶进行了详细的构象分析，以确定影响取代基诱导的受限旋转运动的因素。这项研究将旋转过程中涉及的过渡态的计算研究与受限旋转产生的旋转异构体的实验表征相结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/54298cb5e8eb/ol5c02839_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/bd7d030dec0b/ol5c02839_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/6e904620846b/ol5c02839_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/f386ac30221c/ol5c02839_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/c7afad049341/ol5c02839_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/23f360350de5/ol5c02839_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/54298cb5e8eb/ol5c02839_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/bd7d030dec0b/ol5c02839_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/6e904620846b/ol5c02839_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/f386ac30221c/ol5c02839_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/c7afad049341/ol5c02839_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/23f360350de5/ol5c02839_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff4a/12418502/54298cb5e8eb/ol5c02839_0006.jpg

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本文引用的文献

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J Pharm Anal. 2024 May;14(5):100919. doi: 10.1016/j.jpha.2023.12.009. Epub 2023 Dec 12.
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Cytisine: State of the art in pharmacological activities and pharmacokinetics.烟碱型乙酰胆碱受体激动剂：药理学活性和药代动力学的研究现状。
Biomed Pharmacother. 2024 Feb;171:116210. doi: 10.1016/j.biopha.2024.116210. Epub 2024 Jan 24.
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Bispidine as a promising scaffold for designing molecular machines.
双吡啶作为设计分子机器的一种有前景的骨架。
Org Biomol Chem. 2023 Nov 22;21(45):9054-9060. doi: 10.1039/d3ob01406a.
4
Bispidine as a Versatile Scaffold: From Topological Hosts to Transmembrane Transporters.双吡啶作为一种多功能支架：从拓扑主体到跨膜转运体。
Chembiochem. 2023 Dec 1;24(23):e202300502. doi: 10.1002/cbic.202300502. Epub 2023 Oct 10.
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Bispidine Platform as a Tool for Studying Amide Configuration Stability.双哌啶平台作为研究酰胺构型稳定性的工具。
Molecules. 2022 Jan 10;27(2):430. doi: 10.3390/molecules27020430.
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Chem Sci. 2021 Oct 25;12(47):15757-15764. doi: 10.1039/d1sc04860k. eCollection 2021 Dec 8.
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