Danakas Alexandra M, Bsirini Caroline, Miyamoto Hiroshi
Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY, 14642, USA.
Department of Urology, University of Rochester Medical Center, Rochester, NY, USA.
Pathol Oncol Res. 2018 Oct;24(4):947-950. doi: 10.1007/s12253-018-0439-z. Epub 2018 Jun 3.
No recent studies have focused on assessing the role of intraoperative frozen section assessment (FSA) in the status of surgical margins (SMs) relating to the outcomes of penectomy cases. In this study, we investigated the utility of routine FSA of the SMs in men undergoing penectomy. A retrospective review identified consecutive patients who underwent partial (n = 26) or total (n = 12) penectomy for penile squamous cell carcinoma at our institution from 2004 to 2015. FSA of the SMs was performed in 21 (80.8%) partial and 10 (83.3%) total penectomies. FSAs were reported as positive (n = 3, 9.7%), atypical (n = 3, 9.7%), and negative (n = 25, 80.6%). All of the positive or negative FSA diagnoses were confirmed accurate on the frozen section controls, whereas the 3 cases with atypical FSA had non-malignant, atypical, and carcinoma cells, respectively, on the controls. Final SMs were positive in 6 (15.8%) penectomies, including 4 (12.9%) FSA cases versus 2 (28.6%) non-FSA cases (P = 0.569). Furthermore, initial positive (1 of 3) and atypical (3 of 3) FSA cases achieved negative conversion by excision of additional tissue sent for FSA. Kaplan-Meier analysis revealed that performing FSA or its number/diagnosis was not significantly associated with disease progression. Thus, performing FSA during penectomy does not appear to have any significant impact on final SM status nor long-term oncologic outcomes. However, as seen in at least 4 cases, select patients may benefit from the routine FSA.
近期尚无研究聚焦于评估术中冰冻切片评估（FSA）在阴茎切除术病例的手术切缘（SMs）状态及相关预后中的作用。在本研究中，我们调查了阴茎切除术男性患者中对SMs进行常规FSA的效用。一项回顾性研究纳入了2004年至2015年在我们机构接受部分阴茎切除（n = 26）或全阴茎切除（n = 12）治疗阴茎鳞状细胞癌的连续患者。21例（80.8%）部分阴茎切除术和10例（83.3%）全阴茎切除术进行了SMs的FSA。FSA报告为阳性（n = 3，9.7%）、非典型（n = 3，9.7%）和阴性（n = 25，80.6%）。所有阳性或阴性FSA诊断在冰冻切片对照中均被证实准确，而3例非典型FSA病例在对照中分别有非恶性、非典型和癌细胞。最终SMs在6例（15.
