Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas 77030, USA.
Pathology. 2012 Aug;44(5):427-33. doi: 10.1097/PAT.0b013e328356a79e.
Frozen section diagnosis provides critical information for immediate surgical management decision making. Over the last several years, there have been some significant advances in treatment of genitourinary cancer, particularly with regard to surgical techniques. These changes in turn impact the type and frequency of intraoperative frozen section requests. In this review, we describe the main indications and diagnostic challenges of frozen section diagnosis during surgeries of each genitourinary organ system including prostate, kidney, bladder, testis, and penis. The pitfalls and approaches to different diagnostic situations are discussed. It is also stressed that pathologists must not only be familiar with the histological diagnosis, but also understand the limitations of frozen section diagnosis and communicate with urologists during the intraoperative treatment decision making process.
冰冻切片诊断为即时手术管理决策提供关键信息。在过去的几年中，泌尿生殖系统癌症的治疗取得了一些重大进展，特别是在手术技术方面。这些变化反过来又影响了术中冰冻切片请求的类型和频率。在这篇综述中，我们描述了包括前列腺、肾脏、膀胱、睾丸和阴茎在内的每个泌尿生殖系统器官手术中冰冻切片诊断的主要适应证和诊断挑战。讨论了不同诊断情况的陷阱和方法。还强调病理学家不仅必须熟悉组织学诊断，还必须了解冰冻切片诊断的局限性，并在术中治疗决策过程中与泌尿科医生进行沟通。
