Department of Obstetrics and Gynecology, Clinical Division of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Vienna, Austria.
Karl Landsteiner Institut fuer Spezielle Gynaekologie und Geburtshilfe, Vienna, Austria.
Int J Gynaecol Obstet. 2018 Sep;142(3):365-369. doi: 10.1002/ijgo.12545. Epub 2018 Jun 28.
To assess associations between anterior and/or fundal uterine leiomyoma and overactive bladder syndrome.
The present cohort study recruited women diagnosed with fundal/anterior uterine leiomyoma by standardized transvaginal ultrasonography at the Medical University of Vienna, Austria, between January 1, 2010, and December 31, 2013, in addition to an age-matched control group of women without uterine leiomyoma. The International Consultation on Incontinence Questionnaire Overactive Bladder Module (ICIQ-OAB) was mailed to all eligible participants. The main outcome was the ICIQ-OAB sum score.
Among 304 questionnaires sent out, 129 were returned. After the exclusion of incomplete datasets, 80 women were included in the analysis (uterine leiomyoma group, 43; control group, 37). The mean ± SD ICIQ-OAB sum score was 9.7 ± 10.2 for women with uterine leiomyoma and 4.2 ± 5.3 for women in the control group; thus, the ICIQ-OAB sum score was on average 5.5 points higher in the uterine leiomyoma group (P=0.003). The Spearman correlation coefficient between the total volume of leiomyoma per woman and the ICIQ-OAB sum score was 0.072 (P=0.645).
The study found a significant association between anterior and/or fundal leiomyoma and overactive bladder syndrome. The presence of uterine leiomyoma should be ruled out during the evaluation of overactive bladder.
评估前壁和（或）底部子宫肌瘤与膀胱过度活动症之间的关联。
本队列研究招募了 2010 年 1 月 1 日至 2013 年 12 月 31 日期间在奥地利维也纳医科大学通过标准化经阴道超声诊断为底部/前壁子宫肌瘤的女性，以及年龄匹配的无子宫肌瘤女性对照组。向所有符合条件的参与者邮寄国际尿失禁咨询问卷膀胱过度活动症模块（ICIQ-OAB）。主要结局是 ICIQ-OAB 总分。
在寄出的 304 份问卷中，有 129 份被退回。剔除不完整数据集后，有 80 名女性被纳入分析（子宫肌瘤组 43 名；对照组 37 名）。子宫肌瘤组女性的 ICIQ-OAB 总分平均值±标准差为 9.7±10.2，对照组女性为 4.2±5.3；因此，子宫肌瘤组的 ICIQ-OAB 总分平均高出 5.5 分（P=0.003）。每位女性的子宫肌瘤总体积与 ICIQ-OAB 总分之间的 Spearman 相关系数为 0.072（P=0.645）。
本研究发现前壁和（或）底部子宫肌瘤与膀胱过度活动症之间存在显著关联。在评估膀胱过度活动症时应排除子宫肌瘤的存在。
