Wang Xiaoqin, Jia Zhongzhi, Shi Haifeng, Pan Changjie
Department of Radiology, Changzhou No. 2 People's Hospital, Changzhou, Jiangsu, China.
Department of Interventional Radiology, Changzhou No. 2 People's Hospital, Changzhou, Jiangsu, China.
Clin Exp Pharmacol Physiol. 2018 Oct;45(10):1083-1086. doi: 10.1111/1440-1681.12977.
The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysregulated in NSCLC patients (P < .001). When applied for NSCLC diagnosis, combined application of miR-21 and let-7a had a sensitivity of 0.790, specificity of 0.750, which is significantly higher than application alone of miR-21(sensitivity 0.647; specificity 0.641), let-7a (sensitivity 0.653; specificity 0.718) or computed tomography-guided core-needle biopsy (CTCB) (sensitivity 0.725; specificity 0.609) (P < .01). In conclusion, our study indicates that combined application of circulating miR-21 and let-7a has advantages over traditional CTCB technique.
循环中的微小RNA（miRNA）在非小细胞肺癌（NSCLC）中表达失调，在临床诊断方面具有巨大潜力。本研究旨在筛选并评估用于NSCLC诊断的候选血清miRNA的可靠性和诊断效率。我们发现，miR-21和let-7a在NSCLC患者中显著失调（P < 0.001）。当用于NSCLC诊断时，联合应用miR-21和let-7a的敏感性为0.790，特异性为0.750，显著高于单独应用miR-21（敏感性0.647；特异性0.641）、let-7a（敏感性0.653；特异性0.718）或计算机断层扫描引导下的粗针活检（CTCB）（敏感性0.725；特异性0.609）（P < 0.01）。总之，我们的研究表明，循环miR-21和let-7a的联合应用优于传统的CTCB技术。
