Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.
School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.
Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9408-9412. doi: 10.1002/anie.201805052. Epub 2018 Jun 22.
Oxidative stress induced by reactive oxygen species (ROS) is one of the critical factors that involves in the pathogenesis and progression of many diseases. However, lack of proper techniques to scavenge ROS depending on their cellular localization limits a thorough understanding of the pathological effects of ROS. Here, we demonstrate the selective scavenging of mitochondrial, intracellular, and extracellular ROS using three different types of ceria nanoparticles (NPs), and its application to treat Parkinson's disease (PD). Our data show that scavenging intracellular or mitochondrial ROS inhibits the microglial activation and lipid peroxidation, while protecting the tyrosine hydroxylase (TH) in the striata of PD model mice. These results indicate the essential roles of intracellular and mitochondrial ROS in the progression of PD. We anticipate that our ceria NP systems will serve as a useful tool for elucidating the functions of various ROS in diseases.
活性氧（ROS）引起的氧化应激是涉及许多疾病发病机制和进展的关键因素之一。然而，由于缺乏适当的技术来清除取决于其细胞定位的 ROS，因此对 ROS 的病理作用的理解还不够深入。在这里，我们使用三种不同类型的氧化铈纳米粒子（NPs）来选择性地清除线粒体、细胞内和细胞外 ROS，并将其应用于治疗帕金森病（PD）。我们的数据表明，清除细胞内或线粒体 ROS 可抑制小胶质细胞的激活和脂质过氧化，同时保护 PD 模型小鼠纹状体中的酪氨酸羟化酶（TH）。这些结果表明细胞内和线粒体 ROS 在 PD 的进展中起重要作用。我们预计我们的氧化铈 NP 系统将成为阐明各种 ROS 在疾病中的功能的有用工具。
