Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada.
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Diseases, US Centers for Disease Control and Prevention, Anchorage, Alaska, USA.
Int J Tuberc Lung Dis. 2018 Jun 1;22(6):641-648. doi: 10.5588/ijtld.17.0525.
The northern circumpolar jurisdictions Canada (Northwest Territories, Nunavik, Nunavut, Yukon), Finland, Greenland, Norway, Russian Federation (Arkhangelsk), Sweden and the United States (Alaska).
To describe and compare demographic, clinical and laboratory characteristics, including drug resistance and treatment completion, of tuberculosis (TB) cases in the northern circumpolar populations.
Descriptive analysis of all active TB cases reported from 2006 to 2012 for incidence rate (IR), age and sex distribution, sputum smear and diagnostic site characteristics, drug resistance and treatment completion rates.
The annual IR of TB disease ranged from a low of 4.3 per 100 000 population in Northern Sweden to a high of 199.5/100 000 in Nunavik, QC, Canada. For all jurisdictions, IR was higher for males than for females. Yukon had the highest proportion of new cases compared with retreatment cases (96.6%). Alaska reported the highest percentage of laboratory-confirmed cases (87.4%). Smear-positive pulmonary cases ranged from 25.8% to 65.2%. Multidrug-resistant cases ranged from 0% (Northern Canada) to 46.3% (Arkhangelsk). Treatment outcome data, available up to 2011, demonstrated >80% treatment completion for four of the 10 jurisdictions.
TB remains a serious public health issue in the circumpolar regions. Surveillance data contribute toward a better understanding and improved control of TB in the north.
加拿大（西北地区、努纳武特地区、育空地区、努纳维克地区）、芬兰、格陵兰、挪威、俄罗斯联邦（阿尔汉格尔斯克）、瑞典和美国（阿拉斯加）等北极圈国家。
描述并比较北极圈人群中结核病（TB）病例的人口统计学、临床和实验室特征，包括耐药性和治疗完成情况。
对 2006 年至 2012 年期间报告的所有活动性肺结核病例进行描述性分析，包括发病率（IR）、年龄和性别分布、痰涂片和诊断部位特征、耐药性和治疗完成率。
结核病疾病的年发病率从北部瑞典的 4.3/100000 到加拿大魁北克省努纳武特地区的 199.5/100000 不等。所有司法管辖区的男性发病率均高于女性。育空地区新发病例比例（96.6%）高于复治病例。阿拉斯加报告的实验室确诊病例比例最高（87.4%）。涂片阳性的肺部病例比例从 25.8%到 65.2%不等。耐多药病例比例从 0%（加拿大北部）到 46.3%（阿尔汉格尔斯克）不等。截至 2011 年，可获得的治疗结果数据表明，10 个司法管辖区中有 4 个的治疗完成率超过 80%。
结核病仍然是北极地区严重的公共卫生问题。监测数据有助于更好地了解和改善北方的结核病控制。
