经吸入长期给予乙醛对大鼠脑膜（钠+钾）激活的三磷酸腺苷酶活性的影响。
Effect of chronic administration of acetaldehyde by inhalation on (Na+ + K+)-activated adenosine triphosphatase activity of rat brain membranes.
作者信息
Shiohara E, Tsukada M, Chiba S, Yamazaki H, Nishiguchi K, Miyamoto R, Nakanishi S
出版信息
Toxicology. 1985 Mar 29;34(4):277-84. doi: 10.1016/0300-483x(85)90138-6.
The effect of chronic acetaldehyde inhalation on (Na+ + K+)-ATPase (EC 3.6.1.3) activities of subcellular fractions of the rat cerebral cortex was studied. Chronic administration of acetaldehyde by inhalation for 4-21 weeks caused significant increases in the enzyme activities of both the synaptosomal plasma membrane (SPM) fraction and the microsomal (MC) fraction. This indicates the change in neural membrane functions of the brain after acetaldehyde treatment. Mg2+-ATPase activities of both subcellular fractions remained unchanged after acetaldehyde treatment.
研究了慢性吸入乙醛对大鼠大脑皮质亚细胞组分中（Na⁺ + K⁺）-ATP酶（EC 3.6.1.3）活性的影响。通过吸入方式对大鼠进行4至21周的慢性乙醛给药后，突触体细胞膜（SPM）组分和微粒体（MC）组分中的酶活性均显著增加。这表明乙醛处理后大脑神经膜功能发生了变化。乙醛处理后，两个亚细胞组分的Mg²⁺-ATP酶活性均保持不变。
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