Müller R P, Peters P E
Strahlentherapie. 1985 Apr;161(4):239-43.
In sixteen patients who had been treated 42 months before on an average for malignant melanomas of the lower extremity (stage I) by a unilateral endolymphatic therapy with 32P/131J-Lipiodol UF, bipedal lymphography with oily contrast medium was performed. In consequence of the high-dosed intralymphatic radiotherapy the lymph nodes of the treated side are markedly reduced in size and number; fourteen out of the sixteen patients, however, showed lymph nodes of normal size and structure which had not been coloured during ELRT. On the basis of this phenomenon, a possible mechanism of formation of metastases in previously treated lymph nodes is discussed. The presentation and extent of radiogenic reactions in the lymph vessels correspond to the changes known for percutaneous irradiation.
16例患者平均在42个月前曾接受过单侧内淋巴放射治疗（使用32P/131I -超液态碘化油），以治疗下肢恶性黑色素瘤（I期）。之后对这些患者进行了使用油性造影剂的双足淋巴造影。由于高剂量的淋巴管内放射治疗，治疗侧的淋巴结在大小和数量上明显减少；然而，16例患者中有14例显示出大小和结构正常的淋巴结，这些淋巴结在内淋巴放射治疗期间未被染色。基于这一现象，讨论了先前治疗过的淋巴结中转移灶形成的可能机制。淋巴管中放射反应的表现和程度与经皮照射已知的变化相符。
